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- W2890829280 abstract "Abstract Background A pediatric vaccine to prevent breast milk transmission of human immunodeficiency virus (HIV) may generate greater immune responses at viral entry sites if given by an oral route. Methods We compared immune responses induced in juvenile macaques by prime/boosting with simian immunodeficiency virus (SIV)‐expressing DNA/modified vaccinia Ankara virus (MVA) by the intramuscular route (IM), the oral (O)/tonsillar routes (T), the O/sublingual (SL) routes, and O+IM/SL routes. Results O/T or O/SL immunization generated SIV‐specific T cells in mucosal tissues but failed to induce SIV‐specific IgA in saliva or stool or IgG in plasma. IM/IM or O+IM/SL generated humoral and cellular responses to SIV. IM/IM generated greater frequencies of T FH in spleen, but O+IM/SL animals had higher avidity plasma IgG and more often demonstrated mucosal IgA responses. Conclusion These results suggest that codelivery of HIV DNA/MVA vaccines by the oral and IM routes might be optimal for generating both systemic and mucosal antibodies." @default.
- W2890829280 created "2018-09-27" @default.
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- W2890829280 date "2018-09-11" @default.
- W2890829280 modified "2023-10-01" @default.
- W2890829280 title "A simultaneous oral and intramuscular prime/sublingual boost with a DNA/Modified Vaccinia Ankara viral vector-based vaccine induces simian immunodeficiency virus-specific systemic and mucosal immune responses in juvenile rhesus macaques" @default.
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- W2890829280 doi "https://doi.org/10.1111/jmp.12372" @default.
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