FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890831324> ?p ?o ?g. }

• W2890831324 endingPage "196" @default.
• W2890831324 startingPage "187" @default.
• W2890831324 abstract "The incidence of carcinomas highly increases with age. However, the initial steps of the age-related molecular carcinogenic processes remain poorly characterized. We previously showed that normal human epidermal keratinocytes spontaneously and systematically escape from senescence to give rise to preneoplastic emerging cells through a process called post-senescence neoplastic emergence (PSNE). To identify molecular pathways involved in the switch from senescence to pre-transformation, we performed Connectivity Map analyses and DAVID functional annotations followed by hierarchical clustering and multidimensional scaling of the gene expression signature of PSNE cells. We identified endoplasmic reticulum stress related pathways as key regulators of PSNE. Invalidation by RNA interference of the UPR sensors PERK, ATF6α, but not IRE1α, delayed the occurrence of senescence when performed in pre-senescent cells, and increased the PSNE frequency when performed in already senescent cells. Conversely, endoplasmic reticulum stress inducers applied to already senescent cells decreased the frequency of PSNE. In conclusion, these results indicate that the activation of the UPR could protect from the early carcinogenic steps by senescence evasion. This opens new avenues to explore therapeutics that could be useful in decreasing the age-associated tumor incidence." @default.
• W2890831324 created "2018-09-27" @default.
• W2890831324 creator A5004634086 @default.
• W2890831324 creator A5011704586 @default.
• W2890831324 creator A5022970803 @default.
• W2890831324 creator A5034487780 @default.
• W2890831324 creator A5044537062 @default.
• W2890831324 creator A5051345899 @default.
• W2890831324 creator A5052244707 @default.
• W2890831324 creator A5058983709 @default.
• W2890831324 creator A5067217736 @default.
• W2890831324 creator A5089830476 @default.
• W2890831324 date "2018-12-01" @default.
• W2890831324 modified "2023-09-25" @default.
• W2890831324 title "Pre-malignant transformation by senescence evasion is prevented by the PERK and ATF6alpha branches of the Unfolded Protein Response" @default.
• W2890831324 cites W1044743974 @default.
• W2890831324 cites W1565166977 @default.
• W2890831324 cites W1970594724 @default.
• W2890831324 cites W1974191631 @default.
• W2890831324 cites W1981515291 @default.
• W2890831324 cites W1983688352 @default.
• W2890831324 cites W1989479849 @default.
• W2890831324 cites W2003652428 @default.
• W2890831324 cites W2006521831 @default.
• W2890831324 cites W2007872313 @default.
• W2890831324 cites W2010417927 @default.
• W2890831324 cites W2020333730 @default.
• W2890831324 cites W2024209230 @default.
• W2890831324 cites W2030739080 @default.
• W2890831324 cites W2031792875 @default.
• W2890831324 cites W2045264627 @default.
• W2890831324 cites W2053442171 @default.
• W2890831324 cites W2057932613 @default.
• W2890831324 cites W2059280539 @default.
• W2890831324 cites W2069519394 @default.
• W2890831324 cites W2072730583 @default.
• W2890831324 cites W2080100430 @default.
• W2890831324 cites W2083966893 @default.
• W2890831324 cites W2086793178 @default.
• W2890831324 cites W2093398011 @default.
• W2890831324 cites W2093560519 @default.
• W2890831324 cites W2094807512 @default.
• W2890831324 cites W2115852450 @default.
• W2890831324 cites W2121604817 @default.
• W2890831324 cites W2123484218 @default.
• W2890831324 cites W2124614845 @default.
• W2890831324 cites W2133388626 @default.
• W2890831324 cites W2133465414 @default.
• W2890831324 cites W2143224622 @default.
• W2890831324 cites W2158217645 @default.
• W2890831324 cites W2160956377 @default.
• W2890831324 cites W2162294575 @default.
• W2890831324 cites W2217986049 @default.
• W2890831324 cites W2266290735 @default.
• W2890831324 cites W2288640949 @default.
• W2890831324 cites W2314039647 @default.
• W2890831324 cites W2341812625 @default.
• W2890831324 cites W2516949558 @default.
• W2890831324 cites W2736142588 @default.
• W2890831324 cites W4210349659 @default.
• W2890831324 cites W4232925121 @default.
• W2890831324 doi "https://doi.org/10.1016/j.canlet.2018.09.008" @default.
• W2890831324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30213560" @default.
• W2890831324 hasPublicationYear "2018" @default.
• W2890831324 type Work @default.
• W2890831324 sameAs 2890831324 @default.
• W2890831324 citedByCount "5" @default.
• W2890831324 countsByYear W28908313242019 @default.
• W2890831324 countsByYear W28908313242020 @default.
• W2890831324 countsByYear W28908313242021 @default.
• W2890831324 crossrefType "journal-article" @default.
• W2890831324 hasAuthorship W2890831324A5004634086 @default.
• W2890831324 hasAuthorship W2890831324A5011704586 @default.
• W2890831324 hasAuthorship W2890831324A5022970803 @default.
• W2890831324 hasAuthorship W2890831324A5034487780 @default.
• W2890831324 hasAuthorship W2890831324A5044537062 @default.
• W2890831324 hasAuthorship W2890831324A5051345899 @default.
• W2890831324 hasAuthorship W2890831324A5052244707 @default.
• W2890831324 hasAuthorship W2890831324A5058983709 @default.
• W2890831324 hasAuthorship W2890831324A5067217736 @default.
• W2890831324 hasAuthorship W2890831324A5089830476 @default.
• W2890831324 hasConcept C104317684 @default.
• W2890831324 hasConcept C139447449 @default.
• W2890831324 hasConcept C158617107 @default.
• W2890831324 hasConcept C2778997996 @default.
• W2890831324 hasConcept C2993273003 @default.
• W2890831324 hasConcept C31033888 @default.
• W2890831324 hasConcept C502942594 @default.
• W2890831324 hasConcept C522857546 @default.
• W2890831324 hasConcept C54355233 @default.
• W2890831324 hasConcept C555283112 @default.
• W2890831324 hasConcept C86803240 @default.
• W2890831324 hasConcept C95444343 @default.
• W2890831324 hasConceptScore W2890831324C104317684 @default.
• W2890831324 hasConceptScore W2890831324C139447449 @default.
• W2890831324 hasConceptScore W2890831324C158617107 @default.
• W2890831324 hasConceptScore W2890831324C2778997996 @default.
• W2890831324 hasConceptScore W2890831324C2993273003 @default.

• next