Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890832189> ?p ?o ?g. }
- W2890832189 endingPage "1456" @default.
- W2890832189 startingPage "1448" @default.
- W2890832189 abstract "Objective Adequate nicotinamide adenine dinucleotide (NAD) content in hypothalamic neurons is critical for the maintenance of normal energy balance and circadian rhythm. In this study, the beneficial metabolic effects of chronic NAD supplementation on diet‐induced obesity and obesity‐related disruption of diurnal rhythms were examined. Methods C57BL/6 mice were fed a high‐fat diet (HFD) for 12 weeks and received an intraperitoneal injection of either saline or NAD (1 mg/kg/day) for the last 4 weeks. The control mice were fed a chow diet and injected with saline for the same period. Body weights were monitored daily. Daily rhythms of food intake, energy expenditure, and locomotor activity were measured at the end of NAD treatment. The effect of NAD treatment on the clock gene Period 1 (PER1) transcription was also studied . Results Chronic NAD supplementation significantly attenuated weight gain in HFD‐fed obese mice. Furthermore, NAD treatment recovered the suppressed rhythms in the diurnal locomotor activity patterns in obese mice. In addition, exogenous NAD supply rescued cellular NAD depletion‐induced suppression of PER1 transcriptional activity in hypothalamic neuron cells as well as blunted daily fluctuations of hypothalamic arcuate nucleus PER1 expression in obese mice. Conclusions NAD supplementation showed therapeutic effects in obese mice with altered diurnal behaviors." @default.
- W2890832189 created "2018-09-27" @default.
- W2890832189 creator A5007814314 @default.
- W2890832189 creator A5008433135 @default.
- W2890832189 creator A5022544869 @default.
- W2890832189 creator A5031104910 @default.
- W2890832189 creator A5036720735 @default.
- W2890832189 creator A5049689391 @default.
- W2890832189 creator A5067174572 @default.
- W2890832189 creator A5085550686 @default.
- W2890832189 date "2018-09-01" @default.
- W2890832189 modified "2023-10-17" @default.
- W2890832189 title "Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice" @default.
- W2890832189 cites W1964217378 @default.
- W2890832189 cites W1966782228 @default.
- W2890832189 cites W1968890500 @default.
- W2890832189 cites W1987699071 @default.
- W2890832189 cites W1989674299 @default.
- W2890832189 cites W1996003588 @default.
- W2890832189 cites W1997151200 @default.
- W2890832189 cites W2000437193 @default.
- W2890832189 cites W2009888581 @default.
- W2890832189 cites W2028181099 @default.
- W2890832189 cites W2038011036 @default.
- W2890832189 cites W2039017765 @default.
- W2890832189 cites W2042500733 @default.
- W2890832189 cites W2044697772 @default.
- W2890832189 cites W2051608423 @default.
- W2890832189 cites W2052844204 @default.
- W2890832189 cites W2056265088 @default.
- W2890832189 cites W2066183013 @default.
- W2890832189 cites W2073931907 @default.
- W2890832189 cites W2078851955 @default.
- W2890832189 cites W2082393205 @default.
- W2890832189 cites W2089749987 @default.
- W2890832189 cites W2092950801 @default.
- W2890832189 cites W2097487849 @default.
- W2890832189 cites W2103049241 @default.
- W2890832189 cites W2118649927 @default.
- W2890832189 cites W2132412147 @default.
- W2890832189 cites W2134787700 @default.
- W2890832189 cites W2147712103 @default.
- W2890832189 cites W2149079606 @default.
- W2890832189 cites W2152101492 @default.
- W2890832189 cites W2160700740 @default.
- W2890832189 cites W2170078281 @default.
- W2890832189 cites W2171748049 @default.
- W2890832189 cites W2333910555 @default.
- W2890832189 cites W2531686927 @default.
- W2890832189 cites W2540673742 @default.
- W2890832189 cites W2546015443 @default.
- W2890832189 doi "https://doi.org/10.1002/oby.22263" @default.
- W2890832189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30230244" @default.
- W2890832189 hasPublicationYear "2018" @default.
- W2890832189 type Work @default.
- W2890832189 sameAs 2890832189 @default.
- W2890832189 citedByCount "19" @default.
- W2890832189 countsByYear W28908321892019 @default.
- W2890832189 countsByYear W28908321892020 @default.
- W2890832189 countsByYear W28908321892021 @default.
- W2890832189 countsByYear W28908321892022 @default.
- W2890832189 countsByYear W28908321892023 @default.
- W2890832189 crossrefType "journal-article" @default.
- W2890832189 hasAuthorship W2890832189A5007814314 @default.
- W2890832189 hasAuthorship W2890832189A5008433135 @default.
- W2890832189 hasAuthorship W2890832189A5022544869 @default.
- W2890832189 hasAuthorship W2890832189A5031104910 @default.
- W2890832189 hasAuthorship W2890832189A5036720735 @default.
- W2890832189 hasAuthorship W2890832189A5049689391 @default.
- W2890832189 hasAuthorship W2890832189A5067174572 @default.
- W2890832189 hasAuthorship W2890832189A5085550686 @default.
- W2890832189 hasBestOaLocation W28908321891 @default.
- W2890832189 hasConcept C121446783 @default.
- W2890832189 hasConcept C126322002 @default.
- W2890832189 hasConcept C134018914 @default.
- W2890832189 hasConcept C151279926 @default.
- W2890832189 hasConcept C181199279 @default.
- W2890832189 hasConcept C184738001 @default.
- W2890832189 hasConcept C185592680 @default.
- W2890832189 hasConcept C2491326 @default.
- W2890832189 hasConcept C2776901170 @default.
- W2890832189 hasConcept C2777397205 @default.
- W2890832189 hasConcept C2780360009 @default.
- W2890832189 hasConcept C2780391879 @default.
- W2890832189 hasConcept C38606739 @default.
- W2890832189 hasConcept C511355011 @default.
- W2890832189 hasConcept C55493867 @default.
- W2890832189 hasConcept C71924100 @default.
- W2890832189 hasConcept C75520062 @default.
- W2890832189 hasConcept C86803240 @default.
- W2890832189 hasConceptScore W2890832189C121446783 @default.
- W2890832189 hasConceptScore W2890832189C126322002 @default.
- W2890832189 hasConceptScore W2890832189C134018914 @default.
- W2890832189 hasConceptScore W2890832189C151279926 @default.
- W2890832189 hasConceptScore W2890832189C181199279 @default.
- W2890832189 hasConceptScore W2890832189C184738001 @default.
- W2890832189 hasConceptScore W2890832189C185592680 @default.
- W2890832189 hasConceptScore W2890832189C2491326 @default.