Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890832197> ?p ?o ?g. }
- W2890832197 endingPage "1383" @default.
- W2890832197 startingPage "1377" @default.
- W2890832197 abstract "Gait disturbances are some of the earliest changes in dementia and their monitoring presents an opportunity for early diagnosis. The exact relationship between gait and well-established biomarkers of Alzheimer's disease (AD) remains to be clarified. In this study we compared gait-related measures with cerebrospinal fluid (CSF) markers of AD pathology. We recruited seventeen participants with mild AD in a multi-site study and performed gait assessment as well as lumbar punctures to obtain CSF. CSF Aβ42/Aβ40 and Aβ42/Aβ38 correlated positively with measures of variability (step time and step length) in the clinic-based assessments. This was driven by a negative relationship between gait variability and Aβ40 and Aβ38 but not Aβ42.The amyloid ratios and gait variability measures were also associated with more severe functional impairment. We interpret these data as an indication that increasing amyloid production (i.e., increasing Aβ40 and Aβ38) is associated with diminishing cognitive-motor control of gait. These preliminary results suggest that the two amyloid ratios may be a marker of the earliest disturbances in the interplay between cognitive and motor control which characterize dementia." @default.
- W2890832197 created "2018-09-27" @default.
- W2890832197 creator A5002493210 @default.
- W2890832197 creator A5007718911 @default.
- W2890832197 creator A5020077464 @default.
- W2890832197 creator A5025003387 @default.
- W2890832197 creator A5027863344 @default.
- W2890832197 creator A5032315629 @default.
- W2890832197 creator A5032509951 @default.
- W2890832197 creator A5033361414 @default.
- W2890832197 creator A5035122709 @default.
- W2890832197 creator A5043071365 @default.
- W2890832197 creator A5063560061 @default.
- W2890832197 creator A5067755203 @default.
- W2890832197 creator A5074966822 @default.
- W2890832197 date "2018-09-25" @default.
- W2890832197 modified "2023-10-11" @default.
- W2890832197 title "Aβ42/Aβ40 and Aβ42/Aβ38 Ratios Are Associated with Measures of Gait Variability and Activities of Daily Living in Mild Alzheimer’s Disease: A Pilot Study" @default.
- W2890832197 cites W1484555888 @default.
- W2890832197 cites W1813451903 @default.
- W2890832197 cites W1972025839 @default.
- W2890832197 cites W1992165389 @default.
- W2890832197 cites W1994133638 @default.
- W2890832197 cites W1997718099 @default.
- W2890832197 cites W2010382959 @default.
- W2890832197 cites W2020439496 @default.
- W2890832197 cites W2034116699 @default.
- W2890832197 cites W2054382208 @default.
- W2890832197 cites W2056920268 @default.
- W2890832197 cites W2078756260 @default.
- W2890832197 cites W2083541023 @default.
- W2890832197 cites W2112519660 @default.
- W2890832197 cites W2115017507 @default.
- W2890832197 cites W2120320261 @default.
- W2890832197 cites W2132524523 @default.
- W2890832197 cites W2136250824 @default.
- W2890832197 cites W2151529239 @default.
- W2890832197 cites W2152279240 @default.
- W2890832197 cites W2153506531 @default.
- W2890832197 cites W2160150599 @default.
- W2890832197 cites W2161184510 @default.
- W2890832197 cites W2195457766 @default.
- W2890832197 cites W2207877462 @default.
- W2890832197 cites W2286113349 @default.
- W2890832197 cites W2601585605 @default.
- W2890832197 cites W2744157997 @default.
- W2890832197 cites W2761020671 @default.
- W2890832197 cites W2786725461 @default.
- W2890832197 cites W2795467294 @default.
- W2890832197 doi "https://doi.org/10.3233/jad-180622" @default.
- W2890832197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6218125" @default.
- W2890832197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30198873" @default.
- W2890832197 hasPublicationYear "2018" @default.
- W2890832197 type Work @default.
- W2890832197 sameAs 2890832197 @default.
- W2890832197 citedByCount "22" @default.
- W2890832197 countsByYear W28908321972019 @default.
- W2890832197 countsByYear W28908321972020 @default.
- W2890832197 countsByYear W28908321972021 @default.
- W2890832197 countsByYear W28908321972022 @default.
- W2890832197 countsByYear W28908321972023 @default.
- W2890832197 crossrefType "journal-article" @default.
- W2890832197 hasAuthorship W2890832197A5002493210 @default.
- W2890832197 hasAuthorship W2890832197A5007718911 @default.
- W2890832197 hasAuthorship W2890832197A5020077464 @default.
- W2890832197 hasAuthorship W2890832197A5025003387 @default.
- W2890832197 hasAuthorship W2890832197A5027863344 @default.
- W2890832197 hasAuthorship W2890832197A5032315629 @default.
- W2890832197 hasAuthorship W2890832197A5032509951 @default.
- W2890832197 hasAuthorship W2890832197A5033361414 @default.
- W2890832197 hasAuthorship W2890832197A5035122709 @default.
- W2890832197 hasAuthorship W2890832197A5043071365 @default.
- W2890832197 hasAuthorship W2890832197A5063560061 @default.
- W2890832197 hasAuthorship W2890832197A5067755203 @default.
- W2890832197 hasAuthorship W2890832197A5074966822 @default.
- W2890832197 hasBestOaLocation W28908321971 @default.
- W2890832197 hasConcept C118552586 @default.
- W2890832197 hasConcept C126322002 @default.
- W2890832197 hasConcept C151800584 @default.
- W2890832197 hasConcept C15744967 @default.
- W2890832197 hasConcept C169900460 @default.
- W2890832197 hasConcept C173906292 @default.
- W2890832197 hasConcept C1862650 @default.
- W2890832197 hasConcept C2779134260 @default.
- W2890832197 hasConcept C2779483572 @default.
- W2890832197 hasConcept C2779651940 @default.
- W2890832197 hasConcept C2780066322 @default.
- W2890832197 hasConcept C2908551600 @default.
- W2890832197 hasConcept C2984915365 @default.
- W2890832197 hasConcept C502032728 @default.
- W2890832197 hasConcept C71924100 @default.
- W2890832197 hasConcept C99508421 @default.
- W2890832197 hasConceptScore W2890832197C118552586 @default.
- W2890832197 hasConceptScore W2890832197C126322002 @default.
- W2890832197 hasConceptScore W2890832197C151800584 @default.
- W2890832197 hasConceptScore W2890832197C15744967 @default.
- W2890832197 hasConceptScore W2890832197C169900460 @default.
- W2890832197 hasConceptScore W2890832197C173906292 @default.