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- W2890835729 abstract "Fungi have long been a prolific source of natural products that become FDA-approved medicines for bacterial infections, immune disorders, high blood pressure, and other conditions. Over 5 million fungal species, each with as many as 80 natural product biosynthetic pathways, are estimated to exist. But scientists can only culture a small fraction of fungi in the lab, and fungi don’t express all their biosynthetic gene clusters actively. In the past, researchers have produced several fungal natural products by engineering them into readily cultured microorganisms like yeast. Maureen E. Hillenmeyer and Colin J. B. Harvey of Stanford University School of Medicine and coworkers have now developed a more comprehensive fungal natural product discovery system (Sci. Adv. 2018, DOI: 10.1126/sciadv.aar5459). In this system, called HEx (heterologous expression), the researchers identify relevant gene clusters in fungal sequence databases, endow promising ones with high-producing promoters, engineer them into yeast, and collect and analyze the" @default.
- W2890835729 created "2018-09-27" @default.
- W2890835729 creator A5017391316 @default.
- W2890835729 date "2018-04-16" @default.
- W2890835729 modified "2023-09-27" @default.
- W2890835729 title "Hard-to-get fungal natural products found" @default.
- W2890835729 doi "https://doi.org/10.1021/cen-09616-scicon9" @default.
- W2890835729 hasPublicationYear "2018" @default.
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