Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890836916> ?p ?o ?g. }
- W2890836916 abstract "ABSTRACT Enhancers are important regulatory elements that can control gene activity across vast genetic distances. However, the underlying nature of this regulation remains obscured because it has been difficult to observe in living cells. Here, we visualize the spatial organization and transcriptional output of the key pluripotency regulator Sox2 and its essential enhancer Sox2 Control Region (SCR) in living embryonic stem cells (ESCs). We find that Sox2 and SCR show no evidence of enhanced spatial proximity and that spatial dynamics of this pair is limited over tens of minutes. Sox2 transcription occurs in short, intermittent bursts in ESCs and, intriguingly, we find this activity demonstrates no association with enhancer proximity, suggesting that direct enhancer-promoter contacts do not drive contemporaneous Sox2 transcription. Our study establishes a framework for interrogation of enhancer function in living cells and supports an unexpected mechanism for enhancer control of Sox2 expression that uncouples transcription from enhancer proximity." @default.
- W2890836916 created "2018-09-27" @default.
- W2890836916 creator A5019359363 @default.
- W2890836916 creator A5039788638 @default.
- W2890836916 creator A5047050322 @default.
- W2890836916 creator A5074202449 @default.
- W2890836916 creator A5086725918 @default.
- W2890836916 date "2018-09-05" @default.
- W2890836916 modified "2023-09-23" @default.
- W2890836916 title "Live-Cell Imaging Reveals Enhancer-dependent Sox2 Transcription in the Absence of Enhancer Proximity" @default.
- W2890836916 cites W1540070193 @default.
- W2890836916 cites W1859117663 @default.
- W2890836916 cites W1872581706 @default.
- W2890836916 cites W1873772354 @default.
- W2890836916 cites W1941076503 @default.
- W2890836916 cites W1964963969 @default.
- W2890836916 cites W1968729500 @default.
- W2890836916 cites W1970831058 @default.
- W2890836916 cites W1970956961 @default.
- W2890836916 cites W1971530006 @default.
- W2890836916 cites W1971578941 @default.
- W2890836916 cites W1973062929 @default.
- W2890836916 cites W1973337266 @default.
- W2890836916 cites W1975542854 @default.
- W2890836916 cites W1976414476 @default.
- W2890836916 cites W1977203045 @default.
- W2890836916 cites W1977308882 @default.
- W2890836916 cites W1978902427 @default.
- W2890836916 cites W1981030303 @default.
- W2890836916 cites W1987371782 @default.
- W2890836916 cites W1988294855 @default.
- W2890836916 cites W1989769057 @default.
- W2890836916 cites W1999155341 @default.
- W2890836916 cites W2004448789 @default.
- W2890836916 cites W2008812172 @default.
- W2890836916 cites W2011463791 @default.
- W2890836916 cites W2012049188 @default.
- W2890836916 cites W2017050785 @default.
- W2890836916 cites W2018658338 @default.
- W2890836916 cites W2021894549 @default.
- W2890836916 cites W2022993325 @default.
- W2890836916 cites W2038218774 @default.
- W2890836916 cites W2050090238 @default.
- W2890836916 cites W2050826226 @default.
- W2890836916 cites W2056482755 @default.
- W2890836916 cites W2056743008 @default.
- W2890836916 cites W2060484997 @default.
- W2890836916 cites W2060485452 @default.
- W2890836916 cites W2065006553 @default.
- W2890836916 cites W2068427957 @default.
- W2890836916 cites W2070021921 @default.
- W2890836916 cites W2071241326 @default.
- W2890836916 cites W2082379910 @default.
- W2890836916 cites W2085617302 @default.
- W2890836916 cites W2090037139 @default.
- W2890836916 cites W2091502861 @default.
- W2890836916 cites W2092390808 @default.
- W2890836916 cites W2099540110 @default.
- W2890836916 cites W2102689239 @default.
- W2890836916 cites W2103354991 @default.
- W2890836916 cites W2105764211 @default.
- W2890836916 cites W2106647992 @default.
- W2890836916 cites W2108080167 @default.
- W2890836916 cites W2108382860 @default.
- W2890836916 cites W2112514675 @default.
- W2890836916 cites W2113146724 @default.
- W2890836916 cites W2114866946 @default.
- W2890836916 cites W2115685806 @default.
- W2890836916 cites W2116147219 @default.
- W2890836916 cites W2117757143 @default.
- W2890836916 cites W2121659981 @default.
- W2890836916 cites W2123564569 @default.
- W2890836916 cites W2124985265 @default.
- W2890836916 cites W2127540003 @default.
- W2890836916 cites W2128016314 @default.
- W2890836916 cites W2129788878 @default.
- W2890836916 cites W2130696033 @default.
- W2890836916 cites W2131487299 @default.
- W2890836916 cites W2140425768 @default.
- W2890836916 cites W2161212572 @default.
- W2890836916 cites W2161435642 @default.
- W2890836916 cites W2165682071 @default.
- W2890836916 cites W2168602111 @default.
- W2890836916 cites W2169727662 @default.
- W2890836916 cites W2171096629 @default.
- W2890836916 cites W2233603983 @default.
- W2890836916 cites W2239249333 @default.
- W2890836916 cites W2295297857 @default.
- W2890836916 cites W2315188941 @default.
- W2890836916 cites W2411956266 @default.
- W2890836916 cites W2493763501 @default.
- W2890836916 cites W2523285811 @default.
- W2890836916 cites W2529052661 @default.
- W2890836916 cites W2551092411 @default.
- W2890836916 cites W2556513628 @default.
- W2890836916 cites W2557035210 @default.
- W2890836916 cites W2586637063 @default.
- W2890836916 cites W2599212387 @default.
- W2890836916 cites W2603000633 @default.
- W2890836916 cites W2614144400 @default.