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• W2890837632 abstract "The discovery and lead optimisation of a novel series of SYK inhibitors is described. These were optimised for SYK potency and selectivity against Aurora B. Compounds were profiled in a human skin penetration study to identify a suitable candidate molecule for pre-clinical development. Compound 44 (GSK2646264) was selected for progression and is currently in Phase I clinical trials." @default.
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• W2890837632 date "2018-11-01" @default.
• W2890837632 modified "2023-09-27" @default.
• W2890837632 title "Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease" @default.
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• W2890837632 doi "https://doi.org/10.1016/j.bmcl.2018.09.022" @default.
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