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- W2890845083 abstract "Pre-eclampsia is a common pregnancy complication and caused by both hypertension and proteinuria in pregnancy. During pregnancy, many women have been reported with pre-eclampsiaover the globe each year including Asian countries: Sri Lanka and India. Therefore, it is still required to reduce the rate of preterm birth of babies caused by pre-eclampsia. It has been reported that some of the genes from Epidermal Growth Factor (EGF) Receptor (EGFR) family are associated with pre-eclampsia. To this end, more studies have to be carried out to identify the protein interactions and disease associations in order to reduce the risk of pre-eclampsia. In this paper, a protein interaction network analysis and a disease enrichment analysis of pre-eclampsia were utilized in order to identify EGFR-specific ligands and other proteomics factors associated with pre-eclampsia. This analysis can provide insights into drug target identifications, identifying disease-related sub-networks, understanding disease pathogenic mechanisms etc. Rheumatic disease, hypersensitivity, obesity, arthritis etc. were seemed to be associated with pre-eclampsia. 143 proteins and 287 interactions were identified in protein interaction network of pre-eclampsia including all proteins of EGF family except Epigen. Results show that most of the ligands of EGF family and EGFR contribute to pre-eclampsia, which is associated with several other diseases." @default.
- W2890845083 created "2018-09-27" @default.
- W2890845083 creator A5014847381 @default.
- W2890845083 date "2018-06-23" @default.
- W2890845083 modified "2023-10-17" @default.
- W2890845083 title "Proteomic Analysis of EGFR Specific Ligands in Pre-Eclampsia" @default.
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- W2890845083 doi "https://doi.org/10.1145/3239264.3239273" @default.
- W2890845083 hasPublicationYear "2018" @default.
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