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- W2890846235 abstract "Purpose: Monocytes/macrophages play causal roles in the neointimal hyperplasia after vascular injury through the promotion of inflammation, which associates with restenosis, a major limitation of the coronary angioplasty. The Notch pathway regulates embryonic development and contributes to physiological and pathological processes in adult tissues. We recently showed that Notch signaling triggered by Delta-like 4 (Dll4), one of the Notch ligand, promotes inflammatory responses in macrophages, leading to the development of cardiometabolic disorders. The role of Dll4 in the neointimal hyperplasia, however, remains unknown. This study tested the hypothesis that Dll4-mediated Notch signaling contributes to the lesion formation after vascular injury. Methods and Results: We induced wire-mediated vascular injury to C57BL/6 mice. Vascular injury promotes the expression of Dll4 (N=5, P<0.05), but not Jagged 1, another major Notch ligand. Immunohistochemistry in the lesions co-localized Dll4 expression and Notch ac..." @default.
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- W2890846235 date "2012-11-20" @default.
- W2890846235 modified "2023-09-24" @default.
- W2890846235 title "Abstract 17251: Notch Signaling by Delta-Like 4 In Macrophages Contributes to Lesion Formation after Vascular Injury" @default.
- W2890846235 hasPublicationYear "2012" @default.
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