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- W2890847676 abstract "Selective heat shock protein 90 (Hsp90) inhibitor SNX-2112 exhibits antitumor activity in multiple cancer cell types. Here, the antitumor activity of SNX-2112 in Nara-H cells was analyzed.Antitumor activity of SNX-2112 was assessed using a cell proliferation assay. We also examined the signalling pathways involved in SNX-2112-mediated autophagy and apoptosis of Nara-H cells by western blot and morphological analyses.Cell proliferation assays demonstrated that SNX-2112 inhibited Nara-H cell growth. Western blotting revealed that SNX-2112 induced apoptosis and autophagy, inhibited mammalian target of rapamycin (mTOR) phosphorylation, and suppressed the mitogen-activated protein kinase (MAPK) signalling pathway. Morphological analysis confirmed that SNX-2112 induced autophagy and apoptosis.SNX-2112 induced autophagy and apoptosis of Nara-H cells by inhibiting mTOR and MAPK pathways. Our results support developing SNX-2112 to treat human soft tissue sarcomas." @default.
- W2890847676 created "2018-09-27" @default.
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- W2890847676 date "2018-09-01" @default.
- W2890847676 modified "2023-10-16" @default.
- W2890847676 title "SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells" @default.
- W2890847676 doi "https://doi.org/10.21873/anticanres.12840" @default.
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- W2890847676 hasPublicationYear "2018" @default.
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