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- W2890849242 abstract "Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17)(q22;q21), resulting in the fusion of the promyelocytic leukemia gene at 15q22 with the retinoic acid receptor α at 17q21. Additionally, all patients with APL who have additional chromosome abnormalities (ACA) and gene mutations are resistant to all-trans retinoic acid (ATRA), the drug that causes disease regression specifically in patients with APL globally. The present study describes a case of a 19-year-old female with APL carrying a novel complex variant translocation t(6;17;15)(p21;q21;q22), add(7)(q32) and an FMS-related tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation. Complete remission was attained following a course of chemotherapy with ATRA and arsenic trioxide. To the best of our knowledge, this is the first report of a novel three-way translocation of 6p21 and a FLT3-ITD mutation involved with APL." @default.
- W2890849242 created "2018-09-27" @default.
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- W2890849242 date "2018-09-06" @default.
- W2890849242 modified "2023-10-16" @default.
- W2890849242 title "The novel three‑way variant t(6;17;15)(p21;q21;q22) in acute promyelocytic leukemia with an FLT3‑ITD mutation: A case report" @default.
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- W2890849242 doi "https://doi.org/10.3892/ol.2018.9413" @default.
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