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• W2890850037 abstract "Since the proper activation of T cells requires the physical interaction with target cells through the formation of immunological synapses (IS), an alteration at this level could be a reason why tumors escape the immune response. As part of their life cycle, it is thought that T cells alternate between a static phase, the IS, and a dynamic phase, the immunological kinapse (IK), depending on high or low antigen sensing. Our investigation performed in tissue samples of human glioma shows that T cells are able to establish synapsing interactions not only with glioma tumorigenic cells, but also with stromal myeloid cells. Particularly, the IS displaying a T cell receptor-rich (TCR-rich) central supramolecular activation cluster (cSMAC) is preferentially established with stromal cells, as opposed to malignant cells. Conversely, T cells in the malignant areas showed distinct morphometric parameters compared with nonneoplastic tissue - the former characterized by an elongated shape, well-suited to kinaptic dynamics. Importantly, high-resolution 3-dimensional analyses demonstrated the existence of bona-fide IK preferentially arranged in malignant areas of the tumor. This imbalance of IS/IK states between these 2 microenvironments reveals the low antigenic sensing of T cells when patrolling tumorigenic cells and reflects the immunoevasive environment of the tumor." @default.
• W2890850037 created "2018-09-27" @default.
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• W2890850037 date "2018-09-20" @default.
• W2890850037 modified "2023-10-18" @default.
• W2890850037 title "Imbalance of immunological synapse-kinapse states reflects tumor escape to immunity in glioblastoma" @default.
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• W2890850037 doi "https://doi.org/10.1172/jci.insight.120757" @default.
• W2890850037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237222" @default.
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• W2890850037 hasPublicationYear "2018" @default.
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