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- W2890854864 endingPage "e1511506" @default.
- W2890854864 startingPage "e1511506" @default.
- W2890854864 abstract "Peptide-based anticancer vaccination aims at stimulating an immune response against one or multiple tumor-associated antigens (TAAs) following immunization with purified, recombinant or synthetically engineered epitopes. Despite high expectations, the peptide-based vaccines that have been explored in the clinic so far had limited therapeutic activity, largely due to cancer cell-intrinsic alterations that minimize antigenicity and/or changes in the tumor microenvironment that foster immunosuppression. Several strategies have been developed to overcome such limitations, including the use of immunostimulatory adjuvants, the co-treatment with cytotoxic anticancer therapies that enable the coordinated release of damage-associated molecular patterns, and the concomitant blockade of immune checkpoints. Personalized peptide-based vaccines are also being explored for therapeutic activity in the clinic. Here, we review recent preclinical and clinical progress in the use of peptide-based vaccines as anticancer therapeutics.Abbreviations: CMP: carbohydrate-mimetic peptide; CMV: cytomegalovirus; DC: dendritic cell; FDA: Food and Drug Administration; HPV: human papillomavirus; MDS: myelodysplastic syndrome; MHP: melanoma helper vaccine; NSCLC: non-small cell lung carcinoma; ODD: orphan drug designation; PPV: personalized peptide vaccination; SLP: synthetic long peptide; TAA: tumor-associated antigen; TNA: tumor neoantigen" @default.
- W2890854864 created "2018-09-27" @default.
- W2890854864 creator A5006320965 @default.
- W2890854864 creator A5010523895 @default.
- W2890854864 creator A5011373942 @default.
- W2890854864 creator A5034225805 @default.
- W2890854864 creator A5049805426 @default.
- W2890854864 creator A5056768522 @default.
- W2890854864 creator A5071827163 @default.
- W2890854864 creator A5074612242 @default.
- W2890854864 date "2018-09-06" @default.
- W2890854864 modified "2023-10-09" @default.
- W2890854864 title "Trial watch: Peptide-based vaccines in anticancer therapy" @default.
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