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• W2890858314 abstract "The heterogeneity of symptoms and complex etiology of depression pose a significant challenge to the personalization of treatment. Meanwhile, the current application of generic treatment approaches to patients with vastly differing biological and clinical profiles is far from optimal. Here, we conduct a meta-review to identify predictors of response to antidepressant therapy in order to select robust input features for machine learning models of treatment response. These machine learning models will allow us to learn associations between patient features and treatment response which have predictive value at the individual patient level; this learning can be optimized by selecting high-quality input features for the model. While current research is difficult to directly apply to the clinic, machine learning models built using knowledge gleaned from current research may become useful clinical tools. The EMBASE and MEDLINE/PubMed online databases were searched from January 1996 to August 2017, using a combination of MeSH terms and keywords to identify relevant literature reviews. We identified a total of 1909 articles, wherein 199 articles met our inclusion criteria. An array of genetic, immune, endocrine, neuroimaging, sociodemographic, and symptom-based predictors of treatment response were extracted, varying widely in clinical utility. Due to heterogeneous sample sizes, effect sizes, publication biases, and methodological disparities across reviews, we could not accurately assess the strength and directionality of every predictor. Notwithstanding our cautious interpretation of the results, we have identified a multitude of predictors that can be used to formulate a priori hypotheses regarding the input features for a computational model. We highlight the importance of large-scale research initiatives and clinically accessible biomarkers, as well as the need for replication studies of current findings. In addition, we provide recommendations for future improvement and standardization of research efforts in this field." @default.
• W2890858314 created "2018-09-27" @default.
• W2890858314 creator A5000006982 @default.
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• W2890858314 creator A5077185046 @default.
• W2890858314 creator A5088319213 @default.
• W2890858314 creator A5089336904 @default.
• W2890858314 date "2019-01-01" @default.
• W2890858314 modified "2023-10-14" @default.
• W2890858314 title "A systematic meta-review of predictors of antidepressant treatment outcome in major depressive disorder" @default.
• W2890858314 cites W105908140 @default.
• W2890858314 cites W1500342109 @default.
• W2890858314 cites W1556853239 @default.
• W2890858314 cites W1583204538 @default.
• W2890858314 cites W1602725881 @default.
• W2890858314 cites W1697553032 @default.
• W2890858314 cites W1759151863 @default.
• W2890858314 cites W1813695827 @default.
• W2890858314 cites W1897149844 @default.
• W2890858314 cites W1966479610 @default.
• W2890858314 cites W1968915964 @default.
• W2890858314 cites W1968996570 @default.
• W2890858314 cites W1970194986 @default.
• W2890858314 cites W1983657519 @default.
• W2890858314 cites W1994672146 @default.
• W2890858314 cites W1996859603 @default.
• W2890858314 cites W2000057753 @default.
• W2890858314 cites W2001084662 @default.
• W2890858314 cites W2002342601 @default.
• W2890858314 cites W2004308605 @default.
• W2890858314 cites W2007217939 @default.
• W2890858314 cites W2008023699 @default.
• W2890858314 cites W2010070030 @default.
• W2890858314 cites W2011951523 @default.
• W2890858314 cites W2012561426 @default.
• W2890858314 cites W2014435820 @default.
• W2890858314 cites W2017734181 @default.
• W2890858314 cites W2018366064 @default.
• W2890858314 cites W2023453911 @default.
• W2890858314 cites W2026131598 @default.
• W2890858314 cites W2027540165 @default.
• W2890858314 cites W2033501320 @default.
• W2890858314 cites W2037230279 @default.
• W2890858314 cites W2042105069 @default.
• W2890858314 cites W2048687961 @default.
• W2890858314 cites W2048776430 @default.
• W2890858314 cites W2058494291 @default.
• W2890858314 cites W2061378977 @default.
• W2890858314 cites W2062397786 @default.
• W2890858314 cites W2064539835 @default.
• W2890858314 cites W2066458367 @default.
• W2890858314 cites W2067495470 @default.
• W2890858314 cites W2068677608 @default.
• W2890858314 cites W2069874147 @default.
• W2890858314 cites W2069943317 @default.
• W2890858314 cites W2074503150 @default.
• W2890858314 cites W2085758661 @default.
• W2890858314 cites W2085807914 @default.
• W2890858314 cites W2086541418 @default.
• W2890858314 cites W2087010412 @default.
• W2890858314 cites W2087761022 @default.
• W2890858314 cites W2091057630 @default.
• W2890858314 cites W2091893560 @default.
• W2890858314 cites W2104345615 @default.
• W2890858314 cites W2106966334 @default.
• W2890858314 cites W2109270323 @default.
• W2890858314 cites W2116733205 @default.
• W2890858314 cites W2117206688 @default.
• W2890858314 cites W2118164359 @default.
• W2890858314 cites W2126228059 @default.
• W2890858314 cites W2131823335 @default.
• W2890858314 cites W2132324173 @default.
• W2890858314 cites W2133285915 @default.
• W2890858314 cites W2137435000 @default.
• W2890858314 cites W2141974739 @default.
• W2890858314 cites W2146640338 @default.
• W2890858314 cites W2147907847 @default.
• W2890858314 cites W2148933229 @default.
• W2890858314 cites W2154709347 @default.
• W2890858314 cites W2157282844 @default.
• W2890858314 cites W2157607979 @default.
• W2890858314 cites W2158151282 @default.
• W2890858314 cites W2162541816 @default.
• W2890858314 cites W2166354081 @default.
• W2890858314 cites W2168253623 @default.
• W2890858314 cites W2171340584 @default.
• W2890858314 cites W2171951639 @default.
• W2890858314 cites W2202313121 @default.
• W2890858314 cites W2239047507 @default.
• W2890858314 cites W2308564678 @default.
• W2890858314 cites W2313919196 @default.

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