Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890859038> ?p ?o ?g. }
- W2890859038 abstract "Abstract Arachidonic acid metabolites epoxyeicosatrienoates (EETs) and hydroxyeicosatetraenoates (HETEs) are important regulators of myocardial blood flow and coronary vascular resistance (CVR), but their mechanisms of action are not fully understood. We identified G protein-coupled receptor 39 ( GPR39) as a microvascular smooth muscle cell (mVSMC) receptor antagonistically regulated by two endogenous eicosanoids: 15-HETE, which stimulates GPR39 to increase mVSMC intracellular calcium and augment microvascular CVR, and 14,15-EET, which inhibits these actions. Furthermore, zinc ion acts as an allosteric modulator of GPR39 to potentiate the efficacy of the two ligands. Our findings will have a major impact on understanding the roles of eicosanoids in cardiovascular physiology and disease, and provide an opportunity for the development of novel GPR39-targeting therapies for cardiovascular disease. One Sentence Summary GPR39 is a microvascular smooth muscle cell receptor regulated by two vasoactive eicosanoids with opposing actions." @default.
- W2890859038 created "2018-09-27" @default.
- W2890859038 creator A5017296972 @default.
- W2890859038 creator A5028336744 @default.
- W2890859038 creator A5034911433 @default.
- W2890859038 creator A5035730229 @default.
- W2890859038 creator A5036711059 @default.
- W2890859038 creator A5043073265 @default.
- W2890859038 creator A5044076598 @default.
- W2890859038 creator A5050768733 @default.
- W2890859038 creator A5053661149 @default.
- W2890859038 creator A5056499233 @default.
- W2890859038 creator A5062913987 @default.
- W2890859038 creator A5068224926 @default.
- W2890859038 creator A5077641942 @default.
- W2890859038 creator A5090074550 @default.
- W2890859038 date "2018-09-19" @default.
- W2890859038 modified "2023-10-01" @default.
- W2890859038 title "Bidirectional Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR" @default.
- W2890859038 cites W1619653867 @default.
- W2890859038 cites W1913730804 @default.
- W2890859038 cites W1970938572 @default.
- W2890859038 cites W1988097101 @default.
- W2890859038 cites W1992303064 @default.
- W2890859038 cites W2007992951 @default.
- W2890859038 cites W2012063163 @default.
- W2890859038 cites W2013529426 @default.
- W2890859038 cites W2015896990 @default.
- W2890859038 cites W2023363608 @default.
- W2890859038 cites W2027504703 @default.
- W2890859038 cites W2028715667 @default.
- W2890859038 cites W2045875564 @default.
- W2890859038 cites W2046402357 @default.
- W2890859038 cites W2070849419 @default.
- W2890859038 cites W2073568350 @default.
- W2890859038 cites W2087033078 @default.
- W2890859038 cites W2088991084 @default.
- W2890859038 cites W2092875386 @default.
- W2890859038 cites W2097794078 @default.
- W2890859038 cites W2100049822 @default.
- W2890859038 cites W2102926849 @default.
- W2890859038 cites W2105050513 @default.
- W2890859038 cites W2117008929 @default.
- W2890859038 cites W2119556059 @default.
- W2890859038 cites W2123920197 @default.
- W2890859038 cites W2129133958 @default.
- W2890859038 cites W2156365091 @default.
- W2890859038 cites W2163127729 @default.
- W2890859038 cites W2182635476 @default.
- W2890859038 cites W2213300165 @default.
- W2890859038 cites W2466734630 @default.
- W2890859038 cites W2520048248 @default.
- W2890859038 cites W2534177880 @default.
- W2890859038 cites W2603875491 @default.
- W2890859038 cites W2776020692 @default.
- W2890859038 cites W2798188082 @default.
- W2890859038 cites W4251287989 @default.
- W2890859038 doi "https://doi.org/10.1101/420406" @default.
- W2890859038 hasPublicationYear "2018" @default.
- W2890859038 type Work @default.
- W2890859038 sameAs 2890859038 @default.
- W2890859038 citedByCount "3" @default.
- W2890859038 countsByYear W28908590382020 @default.
- W2890859038 countsByYear W28908590382021 @default.
- W2890859038 countsByYear W28908590382022 @default.
- W2890859038 crossrefType "posted-content" @default.
- W2890859038 hasAuthorship W2890859038A5017296972 @default.
- W2890859038 hasAuthorship W2890859038A5028336744 @default.
- W2890859038 hasAuthorship W2890859038A5034911433 @default.
- W2890859038 hasAuthorship W2890859038A5035730229 @default.
- W2890859038 hasAuthorship W2890859038A5036711059 @default.
- W2890859038 hasAuthorship W2890859038A5043073265 @default.
- W2890859038 hasAuthorship W2890859038A5044076598 @default.
- W2890859038 hasAuthorship W2890859038A5050768733 @default.
- W2890859038 hasAuthorship W2890859038A5053661149 @default.
- W2890859038 hasAuthorship W2890859038A5056499233 @default.
- W2890859038 hasAuthorship W2890859038A5062913987 @default.
- W2890859038 hasAuthorship W2890859038A5068224926 @default.
- W2890859038 hasAuthorship W2890859038A5077641942 @default.
- W2890859038 hasAuthorship W2890859038A5090074550 @default.
- W2890859038 hasBestOaLocation W28908590381 @default.
- W2890859038 hasConcept C126322002 @default.
- W2890859038 hasConcept C134018914 @default.
- W2890859038 hasConcept C135285700 @default.
- W2890859038 hasConcept C16613235 @default.
- W2890859038 hasConcept C170493617 @default.
- W2890859038 hasConcept C181199279 @default.
- W2890859038 hasConcept C2778078955 @default.
- W2890859038 hasConcept C2779395532 @default.
- W2890859038 hasConcept C2992686903 @default.
- W2890859038 hasConcept C55493867 @default.
- W2890859038 hasConcept C71924100 @default.
- W2890859038 hasConcept C79879829 @default.
- W2890859038 hasConcept C86803240 @default.
- W2890859038 hasConcept C95444343 @default.
- W2890859038 hasConcept C98274493 @default.
- W2890859038 hasConceptScore W2890859038C126322002 @default.
- W2890859038 hasConceptScore W2890859038C134018914 @default.
- W2890859038 hasConceptScore W2890859038C135285700 @default.
- W2890859038 hasConceptScore W2890859038C16613235 @default.