Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890860459> ?p ?o ?g. }
- W2890860459 endingPage "1174" @default.
- W2890860459 startingPage "1165" @default.
- W2890860459 abstract "Abstract Activation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand, aldosterone, plays an important role in sodium reabsorption and blood pressure regulation. However, expression of the MR goes beyond the kidney. It is expressed in a variety of other tissues in which its activation could lead to tissue injury. Indeed, MR activation in the cardiovascular (CV) system has been shown to promote hypertension, fibrosis, and inflammation. Pharmacological blockade of the MR has protective effects in several animal models of CV disease. Furthermore, the use of MR antagonists is beneficial for heart failure patients, preventing mortality and morbidity. A better understanding of the implications of the MR in the setting of CV diseases is critical for refining treatments and improving patient care. The mechanisms involved in the deleterious effects of MR activation are complex and include oxidative stress, inflammation, and fibrosis. This review will discuss the pathological role of the MR in the CV system and the major mechanisms underlying it." @default.
- W2890860459 created "2018-09-27" @default.
- W2890860459 creator A5045630193 @default.
- W2890860459 creator A5055154436 @default.
- W2890860459 creator A5061827333 @default.
- W2890860459 date "2018-09-05" @default.
- W2890860459 modified "2023-10-18" @default.
- W2890860459 title "Mineralocorticoid Receptor and Cardiovascular Disease" @default.
- W2890860459 cites W1669115597 @default.
- W2890860459 cites W1929982114 @default.
- W2890860459 cites W1965301500 @default.
- W2890860459 cites W1971722024 @default.
- W2890860459 cites W1974757421 @default.
- W2890860459 cites W1976244241 @default.
- W2890860459 cites W1977038176 @default.
- W2890860459 cites W1977960627 @default.
- W2890860459 cites W1978736086 @default.
- W2890860459 cites W1979008376 @default.
- W2890860459 cites W1981384991 @default.
- W2890860459 cites W1982177470 @default.
- W2890860459 cites W1985307512 @default.
- W2890860459 cites W1994199177 @default.
- W2890860459 cites W1995354197 @default.
- W2890860459 cites W2000821919 @default.
- W2890860459 cites W2000835501 @default.
- W2890860459 cites W2007589695 @default.
- W2890860459 cites W2008704689 @default.
- W2890860459 cites W2009763464 @default.
- W2890860459 cites W2009971000 @default.
- W2890860459 cites W2010743737 @default.
- W2890860459 cites W2014164772 @default.
- W2890860459 cites W2020877653 @default.
- W2890860459 cites W2021110709 @default.
- W2890860459 cites W2022754362 @default.
- W2890860459 cites W2025255734 @default.
- W2890860459 cites W2027474764 @default.
- W2890860459 cites W2033764622 @default.
- W2890860459 cites W2033813555 @default.
- W2890860459 cites W2036043627 @default.
- W2890860459 cites W2037481669 @default.
- W2890860459 cites W2037612479 @default.
- W2890860459 cites W2040925848 @default.
- W2890860459 cites W2049772614 @default.
- W2890860459 cites W2050729995 @default.
- W2890860459 cites W2059834495 @default.
- W2890860459 cites W2063921946 @default.
- W2890860459 cites W2064658949 @default.
- W2890860459 cites W2065645584 @default.
- W2890860459 cites W2075099672 @default.
- W2890860459 cites W2075739190 @default.
- W2890860459 cites W2081825820 @default.
- W2890860459 cites W2085311779 @default.
- W2890860459 cites W2088455843 @default.
- W2890860459 cites W2091894128 @default.
- W2890860459 cites W2093076255 @default.
- W2890860459 cites W2097773873 @default.
- W2890860459 cites W2100346820 @default.
- W2890860459 cites W2101877864 @default.
- W2890860459 cites W2104209472 @default.
- W2890860459 cites W2104364870 @default.
- W2890860459 cites W2111785233 @default.
- W2890860459 cites W2112099666 @default.
- W2890860459 cites W2116087989 @default.
- W2890860459 cites W2118804137 @default.
- W2890860459 cites W2119084971 @default.
- W2890860459 cites W2122269095 @default.
- W2890860459 cites W2123801122 @default.
- W2890860459 cites W2124370258 @default.
- W2890860459 cites W2133698686 @default.
- W2890860459 cites W2136320665 @default.
- W2890860459 cites W2138612646 @default.
- W2890860459 cites W2139557727 @default.
- W2890860459 cites W2139956969 @default.
- W2890860459 cites W2142604754 @default.
- W2890860459 cites W2144827664 @default.
- W2890860459 cites W2148840917 @default.
- W2890860459 cites W2149081700 @default.
- W2890860459 cites W2149305062 @default.
- W2890860459 cites W2150011193 @default.
- W2890860459 cites W2152072062 @default.
- W2890860459 cites W2152094259 @default.
- W2890860459 cites W2152397139 @default.
- W2890860459 cites W2156250141 @default.
- W2890860459 cites W2156497356 @default.
- W2890860459 cites W2156726829 @default.
- W2890860459 cites W2159648900 @default.
- W2890860459 cites W2160018700 @default.
- W2890860459 cites W2160937709 @default.
- W2890860459 cites W2161927295 @default.
- W2890860459 cites W2163396913 @default.
- W2890860459 cites W2164705414 @default.
- W2890860459 cites W2166001681 @default.
- W2890860459 cites W2168061260 @default.
- W2890860459 cites W2170524644 @default.
- W2890860459 cites W2170899875 @default.
- W2890860459 cites W2180491396 @default.
- W2890860459 cites W2206859595 @default.
- W2890860459 cites W2222589555 @default.