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- W2890864585 abstract "Myogenic regeneration occurs through a chain of events beginning with the output of satellite cells from quiescent state, formation of competent myoblasts and later fusion and differentiation into myofibres. Traditionally, growth factors are used to stimulate muscle regeneration but this involves serious off-target effects, including alterations in cell homeostasis and cancer. In this work, we have studied the use of zinc to trigger myogenic differentiation. We show that zinc promotes myoblast proliferation, differentiation and maturation of myofibres. We demonstrate that this process occurs through the PI3K/Akt pathway, via zinc stimulation of transporter Zip7. Depletion of zinc transporter Zip7 by RNA interference shows reduction of both PI3K/Akt signalling and a significant reduction of multinucleated myofibres and myotubes development. Moreover, we show that mature myofibres, obtained through stimulation with high concentrations of zinc, accumulate zinc and so we hypothesise their function as zinc reservoirs into the cell." @default.
- W2890864585 created "2018-09-27" @default.
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- W2890864585 date "2018-09-11" @default.
- W2890864585 modified "2023-09-29" @default.
- W2890864585 title "Zinc uptake promotes myoblast differentiation via Zip7 transporter and activation of Akt signalling transduction pathway" @default.
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- W2890864585 doi "https://doi.org/10.1038/s41598-018-32067-0" @default.
- W2890864585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6133932" @default.
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