FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890865075> ?p ?o ?g. }

• W2890865075 endingPage "582" @default.
• W2890865075 startingPage "578" @default.
• W2890865075 abstract "Cellular senescence, which is characterized by an irreversible cell-cycle arrest1 accompanied by a distinctive secretory phenotype2, can be induced through various intracellular and extracellular factors. Senescent cells that express the cell cycle inhibitory protein p16INK4A have been found to actively drive naturally occurring age-related tissue deterioration3,4 and contribute to several diseases associated with ageing, including atherosclerosis5 and osteoarthritis6. Various markers of senescence have been observed in patients with neurodegenerative diseases7-9; however, a role for senescent cells in the aetiology of these pathologies is unknown. Here we show a causal link between the accumulation of senescent cells and cognition-associated neuronal loss. We found that the MAPTP301SPS19 mouse model of tau-dependent neurodegenerative disease10 accumulates p16INK4A-positive senescent astrocytes and microglia. Clearance of these cells as they arise using INK-ATTAC transgenic mice prevents gliosis, hyperphosphorylation of both soluble and insoluble tau leading to neurofibrillary tangle deposition, and degeneration of cortical and hippocampal neurons, thus preserving cognitive function. Pharmacological intervention with a first-generation senolytic modulates tau aggregation. Collectively, these results show that senescent cells have a role in the initiation and progression of tau-mediated disease, and suggest that targeting senescent cells may provide a therapeutic avenue for the treatment of these pathologies." @default.
• W2890865075 created "2018-09-27" @default.
• W2890865075 creator A5001242161 @default.
• W2890865075 creator A5004158028 @default.
• W2890865075 creator A5029077651 @default.
• W2890865075 creator A5041036073 @default.
• W2890865075 creator A5081893956 @default.
• W2890865075 creator A5087155224 @default.
• W2890865075 date "2018-09-19" @default.
• W2890865075 modified "2023-10-18" @default.
• W2890865075 title "Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline" @default.
• W2890865075 cites W1753183749 @default.
• W2890865075 cites W1977085416 @default.
• W2890865075 cites W1982763980 @default.
• W2890865075 cites W2004314923 @default.
• W2890865075 cites W2010417927 @default.
• W2890865075 cites W2016044476 @default.
• W2890865075 cites W2026433865 @default.
• W2890865075 cites W2045121269 @default.
• W2890865075 cites W2045625093 @default.
• W2890865075 cites W2047816313 @default.
• W2890865075 cites W2057249855 @default.
• W2890865075 cites W2064487089 @default.
• W2890865075 cites W2069519394 @default.
• W2890865075 cites W2072210142 @default.
• W2890865075 cites W2089895199 @default.
• W2890865075 cites W2100747051 @default.
• W2890865075 cites W2104908670 @default.
• W2890865075 cites W2107959693 @default.
• W2890865075 cites W2109352508 @default.
• W2890865075 cites W2122400789 @default.
• W2890865075 cites W2125084281 @default.
• W2890865075 cites W2135046848 @default.
• W2890865075 cites W2136454944 @default.
• W2890865075 cites W2156427445 @default.
• W2890865075 cites W2167279371 @default.
• W2890865075 cites W2169663442 @default.
• W2890865075 cites W2210634983 @default.
• W2890865075 cites W2224886002 @default.
• W2890865075 cites W2266290735 @default.
• W2890865075 cites W2544670169 @default.
• W2890865075 cites W2605359398 @default.
• W2890865075 cites W2608899726 @default.
• W2890865075 cites W2739438570 @default.
• W2890865075 cites W2765825833 @default.
• W2890865075 cites W2784612915 @default.
• W2890865075 doi "https://doi.org/10.1038/s41586-018-0543-y" @default.
• W2890865075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6206507" @default.
• W2890865075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30232451" @default.
• W2890865075 hasPublicationYear "2018" @default.
• W2890865075 type Work @default.
• W2890865075 sameAs 2890865075 @default.
• W2890865075 citedByCount "705" @default.
• W2890865075 countsByYear W28908650752018 @default.
• W2890865075 countsByYear W28908650752019 @default.
• W2890865075 countsByYear W28908650752020 @default.
• W2890865075 countsByYear W28908650752021 @default.
• W2890865075 countsByYear W28908650752022 @default.
• W2890865075 countsByYear W28908650752023 @default.
• W2890865075 crossrefType "journal-article" @default.
• W2890865075 hasAuthorship W2890865075A5001242161 @default.
• W2890865075 hasAuthorship W2890865075A5004158028 @default.
• W2890865075 hasAuthorship W2890865075A5029077651 @default.
• W2890865075 hasAuthorship W2890865075A5041036073 @default.
• W2890865075 hasAuthorship W2890865075A5081893956 @default.
• W2890865075 hasAuthorship W2890865075A5087155224 @default.
• W2890865075 hasBestOaLocation W28908650752 @default.
• W2890865075 hasConcept C102230213 @default.
• W2890865075 hasConcept C104317684 @default.
• W2890865075 hasConcept C11960822 @default.
• W2890865075 hasConcept C141035611 @default.
• W2890865075 hasConcept C142724271 @default.
• W2890865075 hasConcept C148762608 @default.
• W2890865075 hasConcept C169760540 @default.
• W2890865075 hasConcept C203014093 @default.
• W2890865075 hasConcept C2776914184 @default.
• W2890865075 hasConcept C2777682930 @default.
• W2890865075 hasConcept C2778198054 @default.
• W2890865075 hasConcept C2779134260 @default.
• W2890865075 hasConcept C2779483572 @default.
• W2890865075 hasConcept C2779830541 @default.
• W2890865075 hasConcept C28406088 @default.
• W2890865075 hasConcept C2984863031 @default.
• W2890865075 hasConcept C522857546 @default.
• W2890865075 hasConcept C54355233 @default.
• W2890865075 hasConcept C71924100 @default.
• W2890865075 hasConcept C79879829 @default.
• W2890865075 hasConcept C86803240 @default.
• W2890865075 hasConcept C95444343 @default.
• W2890865075 hasConceptScore W2890865075C102230213 @default.
• W2890865075 hasConceptScore W2890865075C104317684 @default.
• W2890865075 hasConceptScore W2890865075C11960822 @default.
• W2890865075 hasConceptScore W2890865075C141035611 @default.
• W2890865075 hasConceptScore W2890865075C142724271 @default.
• W2890865075 hasConceptScore W2890865075C148762608 @default.
• W2890865075 hasConceptScore W2890865075C169760540 @default.
• W2890865075 hasConceptScore W2890865075C203014093 @default.
• W2890865075 hasConceptScore W2890865075C2776914184 @default.

• next