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- W2890865514 abstract "Abstract Background Sperm capacitation is essential for proper fertilization and is associated with increased sperm hyperactivity ( HA ) and acrosome reaction ( AR ). For successful fertilization, AR timing is critical; accordingly, early spontaneous AR may not facilitate fertilization. Paraoxonase 1 ( PON 1) possesses antioxidant properties which affect sperm capacitation. The association between PON 1, semen parameters, and capacitation is not fully understood. Objective To study PON 1 activity in relation to human sperm hyperactivity and AR . Materials and Methods Semen samples were collected, and parameters were determined (volume, concentration, total sperm count, percentage total motility, and percentage normal morphology) according to World Health Organization ( WHO ) guidelines. AR and hyperactivity were evaluated using FITC ‐ PSA , staining, and computer‐aided sperm analysis ( CASA ). PON 1 activity was assessed using arylesterase activity assay. Results Purified PON 1 inhibited both sperm hyperactivity and AR in a dose‐dependent manner. Native semen PON 1 activity was positively associated with higher sperm concentration and negatively associated with spontaneous acrosome reaction ( sAR ). Discussion and conclusion PON 1 may have a positive effect on fertility via its ability to prevent early spontaneous sperm capacitation and AR before reaching the female genital tract." @default.
- W2890865514 created "2018-09-27" @default.
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- W2890865514 date "2018-09-17" @default.
- W2890865514 modified "2023-09-30" @default.
- W2890865514 title "Paraoxonase 1 (PON1) attenuates sperm hyperactivity and spontaneous acrosome reaction" @default.
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- W2890865514 doi "https://doi.org/10.1111/andr.12552" @default.
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