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• W2890865905 abstract "O-linked N-acetylglucosamine, better known as O-GlcNAc, is a sugar post-translational modification participating in a diverse range of cell functions. Disruptions in the cycling of O-GlcNAc mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), respectively, is a driving force for aberrant cell signaling in disease pathologies, such as diabetes, obesity, Alzheimer's disease, and cancer. Production of UDP-GlcNAc, the metabolic substrate for OGT, by the Hexosamine Biosynthetic Pathway (HBP) is controlled by the input of amino acids, fats, and nucleic acids, making O-GlcNAc a key nutrient-sensor for fluctuations in these macromolecules. The mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) pathways also participate in nutrient-sensing as a means of controlling cell activity and are significant factors in a variety of pathologies. Research into the individual nutrient-sensitivities of the HBP, AMPK, and mTOR pathways has revealed a complex regulatory dynamic, where their unique responses to macromolecule levels coordinate cell behavior. Importantly, cross-talk between these pathways fine-tunes the cellular response to nutrients. Strong evidence demonstrates that AMPK negatively regulates the mTOR pathway, but O-GlcNAcylation of AMPK lowers enzymatic activity and promotes growth. On the other hand, AMPK can phosphorylate OGT leading to changes in OGT function. Complex sets of interactions between the HBP, AMPK, and mTOR pathways integrate nutritional signals to respond to changes in the environment. In particular, examining these relationships using systems biology approaches might prove a useful method of exploring the complex nature of cell signaling. Overall, understanding the complex interactions of these nutrient pathways will provide novel mechanistic information into how nutrients influence health and disease." @default.
• W2890865905 created "2018-09-27" @default.
• W2890865905 creator A5019154875 @default.
• W2890865905 creator A5035406667 @default.
• W2890865905 creator A5043239621 @default.
• W2890865905 date "2018-09-06" @default.
• W2890865905 modified "2023-10-18" @default.
• W2890865905 title "Real Talk: The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling" @default.
• W2890865905 cites W1568866400 @default.
• W2890865905 cites W1574665002 @default.
• W2890865905 cites W1584199233 @default.
• W2890865905 cites W1612870394 @default.
• W2890865905 cites W1652316604 @default.
• W2890865905 cites W1968005873 @default.
• W2890865905 cites W1977946319 @default.
• W2890865905 cites W1982159046 @default.
• W2890865905 cites W1986526693 @default.
• W2890865905 cites W1994978663 @default.
• W2890865905 cites W1996021619 @default.
• W2890865905 cites W2001568034 @default.
• W2890865905 cites W2002871502 @default.
• W2890865905 cites W2009779581 @default.
• W2890865905 cites W2015357656 @default.
• W2890865905 cites W2016752484 @default.
• W2890865905 cites W2018024152 @default.
• W2890865905 cites W2019677361 @default.
• W2890865905 cites W2023321679 @default.
• W2890865905 cites W2024591818 @default.
• W2890865905 cites W2025176940 @default.
• W2890865905 cites W2025577759 @default.
• W2890865905 cites W2027785297 @default.
• W2890865905 cites W2035020831 @default.
• W2890865905 cites W2035895258 @default.
• W2890865905 cites W2037918682 @default.
• W2890865905 cites W2041379353 @default.
• W2890865905 cites W2045795713 @default.
• W2890865905 cites W2053017792 @default.
• W2890865905 cites W2054722953 @default.
• W2890865905 cites W2054998824 @default.
• W2890865905 cites W2056173710 @default.
• W2890865905 cites W2057068035 @default.
• W2890865905 cites W2058876100 @default.
• W2890865905 cites W2060438440 @default.
• W2890865905 cites W2068663943 @default.
• W2890865905 cites W2073296546 @default.
• W2890865905 cites W2081920342 @default.
• W2890865905 cites W2089632625 @default.
• W2890865905 cites W2098337864 @default.
• W2890865905 cites W2102891343 @default.
• W2890865905 cites W2108966929 @default.
• W2890865905 cites W2109742253 @default.
• W2890865905 cites W2115161053 @default.
• W2890865905 cites W2117026649 @default.
• W2890865905 cites W2121383038 @default.
• W2890865905 cites W2130135884 @default.
• W2890865905 cites W2130755410 @default.
• W2890865905 cites W2132056336 @default.
• W2890865905 cites W2139872039 @default.
• W2890865905 cites W2141869864 @default.
• W2890865905 cites W2142250746 @default.
• W2890865905 cites W2152289580 @default.
• W2890865905 cites W2164814134 @default.
• W2890865905 cites W2418830408 @default.
• W2890865905 cites W2460372346 @default.
• W2890865905 cites W2559588208 @default.
• W2890865905 cites W2586857457 @default.
• W2890865905 cites W2594220918 @default.
• W2890865905 cites W2597833034 @default.
• W2890865905 cites W2625848618 @default.
• W2890865905 cites W2734341870 @default.
• W2890865905 cites W2737043580 @default.
• W2890865905 cites W2763262295 @default.
• W2890865905 cites W2765356256 @default.
• W2890865905 cites W2766921609 @default.
• W2890865905 cites W2767862508 @default.
• W2890865905 cites W2768498974 @default.
• W2890865905 cites W2769172204 @default.
• W2890865905 cites W2782183322 @default.
• W2890865905 cites W2784943238 @default.
• W2890865905 cites W2790027144 @default.
• W2890865905 cites W2790551121 @default.
• W2890865905 cites W2802369762 @default.
• W2890865905 cites W2805110406 @default.
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• W2890865905 doi "https://doi.org/10.3389/fendo.2018.00522" @default.
• W2890865905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6136272" @default.
• W2890865905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30237786" @default.
• W2890865905 hasPublicationYear "2018" @default.
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