Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890868507> ?p ?o ?g. }
- W2890868507 abstract "Abstract Paneth cells are one of the principal epithelial cell types in the small intestine, located at the base of intestinal crypts. Paneth cells play key roles in intestinal host-microbe homeostasis via granule secretion, and their dysfunction is implicated in pathogenesis of several diseases including Crohn’s disease. Despite their physiological importance, study of Paneth cells has been hampered by the limited accessibility and lack of labeling methods. In this study, we developed a simple in vivo imaging method of Paneth cells in the intact mouse small intestine by using moxifloxacin and two-photon microscopy (TPM). Moxifloxacin, an FDA-approved antibiotic, was used for labeling cells and its fluorescence was strongly observed in Paneth cell granules by TPM. Moxifloxacin labeling of Paneth cell granules was confirmed by molecular counterstaining. Comparison of Paneth cells in wild type, genetically obese ( ob / ob ), and germ-free (GF) mice showed different granule distribution. Furthermore, Paneth cell degranulation was observed in vivo . Our study suggests that TPM with moxifloxacin labeling can serve as a useful tool for studying Paneth cell biology and related diseases." @default.
- W2890868507 created "2018-09-27" @default.
- W2890868507 creator A5001769496 @default.
- W2890868507 creator A5003825516 @default.
- W2890868507 creator A5011558968 @default.
- W2890868507 creator A5013124722 @default.
- W2890868507 creator A5018682015 @default.
- W2890868507 creator A5022517705 @default.
- W2890868507 creator A5029411580 @default.
- W2890868507 creator A5033806635 @default.
- W2890868507 creator A5036811221 @default.
- W2890868507 creator A5051451608 @default.
- W2890868507 creator A5052784878 @default.
- W2890868507 creator A5083581120 @default.
- W2890868507 date "2018-09-21" @default.
- W2890868507 modified "2023-10-17" @default.
- W2890868507 title "Two-photon microscopy of Paneth cells in the small intestine of live mice" @default.
- W2890868507 cites W1656401266 @default.
- W2890868507 cites W1784135195 @default.
- W2890868507 cites W1871092986 @default.
- W2890868507 cites W1965758129 @default.
- W2890868507 cites W1968106422 @default.
- W2890868507 cites W1971194480 @default.
- W2890868507 cites W1979138020 @default.
- W2890868507 cites W1979968811 @default.
- W2890868507 cites W1982603620 @default.
- W2890868507 cites W1991625690 @default.
- W2890868507 cites W1993374490 @default.
- W2890868507 cites W1998395322 @default.
- W2890868507 cites W2021799221 @default.
- W2890868507 cites W2022333496 @default.
- W2890868507 cites W2025170824 @default.
- W2890868507 cites W2025482750 @default.
- W2890868507 cites W2042423362 @default.
- W2890868507 cites W2047027201 @default.
- W2890868507 cites W2050908776 @default.
- W2890868507 cites W2052665775 @default.
- W2890868507 cites W2055959752 @default.
- W2890868507 cites W2060928105 @default.
- W2890868507 cites W2061464631 @default.
- W2890868507 cites W2066796559 @default.
- W2890868507 cites W2069683121 @default.
- W2890868507 cites W2072015936 @default.
- W2890868507 cites W2088889535 @default.
- W2890868507 cites W2089371363 @default.
- W2890868507 cites W2097121808 @default.
- W2890868507 cites W2098793175 @default.
- W2890868507 cites W2099662390 @default.
- W2890868507 cites W2105502028 @default.
- W2890868507 cites W2105752232 @default.
- W2890868507 cites W2112567807 @default.
- W2890868507 cites W2122292170 @default.
- W2890868507 cites W2123899348 @default.
- W2890868507 cites W2133728642 @default.
- W2890868507 cites W2137264357 @default.
- W2890868507 cites W2150708165 @default.
- W2890868507 cites W2157010562 @default.
- W2890868507 cites W2158068707 @default.
- W2890868507 cites W2168597652 @default.
- W2890868507 cites W2345421094 @default.
- W2890868507 cites W2404045069 @default.
- W2890868507 cites W2410676187 @default.
- W2890868507 cites W2530571498 @default.
- W2890868507 cites W2589689453 @default.
- W2890868507 doi "https://doi.org/10.1038/s41598-018-32640-7" @default.
- W2890868507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155010" @default.
- W2890868507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30242205" @default.
- W2890868507 hasPublicationYear "2018" @default.
- W2890868507 type Work @default.
- W2890868507 sameAs 2890868507 @default.
- W2890868507 citedByCount "12" @default.
- W2890868507 countsByYear W28908685072019 @default.
- W2890868507 countsByYear W28908685072020 @default.
- W2890868507 countsByYear W28908685072021 @default.
- W2890868507 countsByYear W28908685072023 @default.
- W2890868507 crossrefType "journal-article" @default.
- W2890868507 hasAuthorship W2890868507A5001769496 @default.
- W2890868507 hasAuthorship W2890868507A5003825516 @default.
- W2890868507 hasAuthorship W2890868507A5011558968 @default.
- W2890868507 hasAuthorship W2890868507A5013124722 @default.
- W2890868507 hasAuthorship W2890868507A5018682015 @default.
- W2890868507 hasAuthorship W2890868507A5022517705 @default.
- W2890868507 hasAuthorship W2890868507A5029411580 @default.
- W2890868507 hasAuthorship W2890868507A5033806635 @default.
- W2890868507 hasAuthorship W2890868507A5036811221 @default.
- W2890868507 hasAuthorship W2890868507A5051451608 @default.
- W2890868507 hasAuthorship W2890868507A5052784878 @default.
- W2890868507 hasAuthorship W2890868507A5083581120 @default.
- W2890868507 hasBestOaLocation W28908685071 @default.
- W2890868507 hasConcept C134018914 @default.
- W2890868507 hasConcept C1491633281 @default.
- W2890868507 hasConcept C151730666 @default.
- W2890868507 hasConcept C207001950 @default.
- W2890868507 hasConcept C2776145723 @default.
- W2890868507 hasConcept C2777882243 @default.
- W2890868507 hasConcept C49760210 @default.
- W2890868507 hasConcept C54355233 @default.
- W2890868507 hasConcept C55493867 @default.
- W2890868507 hasConcept C66090201 @default.
- W2890868507 hasConcept C86803240 @default.