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- W2890871692 abstract "Prostate cancer is the most common malignancy affecting men. One diagnostic problem is detection of small foci of prostate cancer in biopsy specimens. Currently, clinical diagnosis of prostate cancer involves an HE however, the specificity to detect prostate cancer cells was 89% (54/61) for the new SP116 clone and 56% (34/61) for clone 13H4. Using the dual assay, the expected staining pattern (p504s -positive/basal cell markers-negative) was observed in 91% (123/135) prostate cancers stained with the new SP116 clone of anti-p504s antibody and basal cell cocktail, while this pattern was observed in 85% (111/131) of cancer cases stained with the Biocare cocktail. In summary, the data from this study indicate that the SP116 clone exhibits similar sensitivity but improved specificity compared to 13H4 clone in detecting malignant prostate glands when used in a single assay on the BenchMark ULTRA instrument. However, the performance of these two clones is similar when used together with basal cell markers in the dual IHC assays. Citation Format: Ryan Miller, Carol Jones, Matthew Buckwalter, Katerina Dvorak. Immunohistochemistry using anti-p504s antibody in prostate cancer: Comparison of novel and on-market antibody clones [abstract]. In: Proceedings of the AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research; 2017 Dec 2-5; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(16 Suppl):Abstract nr A086." @default.
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- W2890871692 date "2018-08-14" @default.
- W2890871692 modified "2023-10-14" @default.
- W2890871692 title "Abstract A086: Immunohistochemistry using anti-p504s antibody in prostate cancer: Comparison of novel and on-market antibody clones" @default.
- W2890871692 doi "https://doi.org/10.1158/1538-7445.prca2017-a086" @default.
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