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- W2890872045 endingPage "e1006344" @default.
- W2890872045 startingPage "e1006344" @default.
- W2890872045 abstract "Filamentous actin (F-actin) and non-muscle myosin II motors drive cell motility and cell shape changes that guide large scale tissue movements during embryonic morphogenesis. To gain a better understanding of the role of actomyosin in vivo, we have developed a two-dimensional (2D) computational model to study emergent phenomena of dynamic unbranched actomyosin arrays in the cell cortex. These phenomena include actomyosin punctuated contractions, or actin asters that form within quiescent F-actin networks. Punctuated contractions involve both formation of high intensity aster-like structures and disassembly of those same structures. Our 2D model allows us to explore the kinematics of filament polarity sorting, segregation of motors, and morphology of F-actin arrays that emerge as the model structure and biophysical properties are varied. Our model demonstrates the complex, emergent feedback between filament reorganization and motor transport that generate as well as disassemble actin asters. Since intracellular actomyosin dynamics are thought to be controlled by localization of scaffold proteins that bind F-actin or their myosin motors we also apply our 2D model to recapitulate in vitro studies that have revealed complex patterns of actomyosin that assemble from patterning filaments and motor complexes with microcontact printing. Although we use a minimal representation of filament, motor, and cross-linker biophysics, our model establishes a framework for investigating the role of other actin binding proteins, how they might alter actomyosin dynamics, and makes predictions that can be tested experimentally within live cells as well as within in vitro models." @default.
- W2890872045 created "2018-09-27" @default.
- W2890872045 creator A5035740521 @default.
- W2890872045 creator A5045824018 @default.
- W2890872045 creator A5046847122 @default.
- W2890872045 creator A5064537167 @default.
- W2890872045 creator A5071484954 @default.
- W2890872045 date "2018-09-17" @default.
- W2890872045 modified "2023-10-01" @default.
- W2890872045 title "Emergent mechanics of actomyosin drive punctuated contractions and shape network morphology in the cell cortex" @default.
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