Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890872159> ?p ?o ?g. }
- W2890872159 endingPage "121" @default.
- W2890872159 startingPage "116" @default.
- W2890872159 abstract "When evaluating consumer products for safety, one must consider the heterogeneity of the population that might use those products, including the potential for different sensitivity based on factors such as age, gender, and genetics. For both systemic endpoints and allergic contact dermatitis (ACD), quantitative safety evaluations typically include a default 10-fold uncertainty/assessment factor to account for inter-individual variability. While this factor is intended to include age, the adequacy of the default 10-fold factor has been questioned for infants, for whom a precautionary assumption is often made that they are more sensitive. In-depth evaluations of the adequacy of the 10-fold factor have been published for systemic endpoints, but relatively little has been published to substantiate this for ACD. This paper reviews the state of the science regarding the etiology of ACD and factors that suggest an overall decreased sensitivity associated with early life exposures, thus confirming the sufficiency of the 10-fold inter-individual factor to provide protection for children and infants. While it remains prudent for all age groups to avoid contact with sensitizers, it is concluded that the quantitative methods used in safety evaluation to prevent the induction of skin sensitization are protective for infants, including neonates and premature infants." @default.
- W2890872159 created "2018-09-27" @default.
- W2890872159 creator A5005592954 @default.
- W2890872159 creator A5031592925 @default.
- W2890872159 creator A5071952153 @default.
- W2890872159 date "2018-11-01" @default.
- W2890872159 modified "2023-09-23" @default.
- W2890872159 title "Allergic contact dermatitis: Adequacy of the default 10X assessment factor for human variability to protect infants and children" @default.
- W2890872159 cites W1433061180 @default.
- W2890872159 cites W1497757655 @default.
- W2890872159 cites W1500128871 @default.
- W2890872159 cites W1552593935 @default.
- W2890872159 cites W1560468264 @default.
- W2890872159 cites W1808682533 @default.
- W2890872159 cites W1850501588 @default.
- W2890872159 cites W1917986903 @default.
- W2890872159 cites W1938177405 @default.
- W2890872159 cites W1966896528 @default.
- W2890872159 cites W1978600948 @default.
- W2890872159 cites W1983242598 @default.
- W2890872159 cites W1983957886 @default.
- W2890872159 cites W1999638889 @default.
- W2890872159 cites W2001500110 @default.
- W2890872159 cites W2002168305 @default.
- W2890872159 cites W2012663457 @default.
- W2890872159 cites W2019206282 @default.
- W2890872159 cites W2025838862 @default.
- W2890872159 cites W2029341221 @default.
- W2890872159 cites W2035912309 @default.
- W2890872159 cites W2041584017 @default.
- W2890872159 cites W2047090987 @default.
- W2890872159 cites W2049802726 @default.
- W2890872159 cites W2062144811 @default.
- W2890872159 cites W2071297831 @default.
- W2890872159 cites W2076090888 @default.
- W2890872159 cites W2076247932 @default.
- W2890872159 cites W2077343145 @default.
- W2890872159 cites W2077846574 @default.
- W2890872159 cites W2079446403 @default.
- W2890872159 cites W2082355065 @default.
- W2890872159 cites W2092160073 @default.
- W2890872159 cites W2092249964 @default.
- W2890872159 cites W2097590976 @default.
- W2890872159 cites W2118283772 @default.
- W2890872159 cites W2123870825 @default.
- W2890872159 cites W2131567343 @default.
- W2890872159 cites W2140970797 @default.
- W2890872159 cites W2155126398 @default.
- W2890872159 cites W2158336796 @default.
- W2890872159 cites W2161291046 @default.
- W2890872159 cites W2177324949 @default.
- W2890872159 cites W2233660390 @default.
- W2890872159 cites W2511959166 @default.
- W2890872159 cites W2792779390 @default.
- W2890872159 cites W4232650143 @default.
- W2890872159 doi "https://doi.org/10.1016/j.yrtph.2018.09.011" @default.
- W2890872159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240832" @default.
- W2890872159 hasPublicationYear "2018" @default.
- W2890872159 type Work @default.
- W2890872159 sameAs 2890872159 @default.
- W2890872159 citedByCount "5" @default.
- W2890872159 countsByYear W28908721592019 @default.
- W2890872159 countsByYear W28908721592020 @default.
- W2890872159 countsByYear W28908721592021 @default.
- W2890872159 crossrefType "journal-article" @default.
- W2890872159 hasAuthorship W2890872159A5005592954 @default.
- W2890872159 hasAuthorship W2890872159A5031592925 @default.
- W2890872159 hasAuthorship W2890872159A5071952153 @default.
- W2890872159 hasBestOaLocation W28908721591 @default.
- W2890872159 hasConcept C126322002 @default.
- W2890872159 hasConcept C137627325 @default.
- W2890872159 hasConcept C187212893 @default.
- W2890872159 hasConcept C203014093 @default.
- W2890872159 hasConcept C207480886 @default.
- W2890872159 hasConcept C2776056826 @default.
- W2890872159 hasConcept C2908647359 @default.
- W2890872159 hasConcept C50440223 @default.
- W2890872159 hasConcept C71924100 @default.
- W2890872159 hasConcept C99454951 @default.
- W2890872159 hasConceptScore W2890872159C126322002 @default.
- W2890872159 hasConceptScore W2890872159C137627325 @default.
- W2890872159 hasConceptScore W2890872159C187212893 @default.
- W2890872159 hasConceptScore W2890872159C203014093 @default.
- W2890872159 hasConceptScore W2890872159C207480886 @default.
- W2890872159 hasConceptScore W2890872159C2776056826 @default.
- W2890872159 hasConceptScore W2890872159C2908647359 @default.
- W2890872159 hasConceptScore W2890872159C50440223 @default.
- W2890872159 hasConceptScore W2890872159C71924100 @default.
- W2890872159 hasConceptScore W2890872159C99454951 @default.
- W2890872159 hasLocation W28908721591 @default.
- W2890872159 hasLocation W28908721592 @default.
- W2890872159 hasOpenAccess W2890872159 @default.
- W2890872159 hasPrimaryLocation W28908721591 @default.
- W2890872159 hasRelatedWork W2080579149 @default.
- W2890872159 hasRelatedWork W2090187928 @default.
- W2890872159 hasRelatedWork W2377142024 @default.
- W2890872159 hasRelatedWork W2899084033 @default.
- W2890872159 hasRelatedWork W3002986063 @default.