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• W2890873042 endingPage "287" @default.
• W2890873042 startingPage "268" @default.
• W2890873042 abstract "Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide, the lifetime risk of developing this disease is 1.5%. Motor diagnostic symptoms of PD are caused by degeneration of nigrostriatal dopamine neurons. There is no cure for PD and current therapy is limited to supportive care that partially alleviates disease signs and symptoms. As diagnostic symptoms of PD result from progressive degeneration of dopamine neurons, drugs restoring these neurons may significantly improve treatment of PD. </P><P> Method: A literature search was performed using the PubMed, Web of Science and Scopus databases to discuss the progress achieved in the development of neuroregenerative agents for PD. Papers published before early 2018 were taken into account. </P><P> Results: Here, we review several groups of potential agents capable of protecting and restoring dopamine neurons in cultures or animal models of PD including neurotrophic factors and small molecular weight compounds. </P><P> Conclusion: Despite the promising results of in vitro and in vivo experiments, none of the found agents have yet shown conclusive neurorestorative properties in PD patients. Meanwhile, a few promising biologicals and small molecules have been identified. Their further clinical development can eventually give rise to disease-modifying drugs for PD. Thus, intensive research in the field is justified." @default.
• W2890873042 created "2018-09-27" @default.
• W2890873042 creator A5039941233 @default.
• W2890873042 creator A5064420566 @default.
• W2890873042 creator A5080317403 @default.
• W2890873042 date "2019-02-14" @default.
• W2890873042 modified "2023-09-23" @default.
• W2890873042 title "Neuroregeneration in Parkinson’s Disease: From Proteins to Small Molecules" @default.
• W2890873042 cites W106605985 @default.
• W2890873042 cites W1146096253 @default.
• W2890873042 cites W1494864007 @default.
• W2890873042 cites W1516316082 @default.
• W2890873042 cites W155726037 @default.
• W2890873042 cites W1574691536 @default.
• W2890873042 cites W1619322898 @default.
• W2890873042 cites W1900535849 @default.
• W2890873042 cites W1965923082 @default.
• W2890873042 cites W1965986364 @default.
• W2890873042 cites W1967659552 @default.
• W2890873042 cites W1968245867 @default.
• W2890873042 cites W1969001730 @default.
• W2890873042 cites W1970828908 @default.
• W2890873042 cites W1971208141 @default.
• W2890873042 cites W1971258758 @default.
• W2890873042 cites W1971598496 @default.
• W2890873042 cites W1971782200 @default.
• W2890873042 cites W1972515739 @default.
• W2890873042 cites W1973061682 @default.
• W2890873042 cites W1974016927 @default.
• W2890873042 cites W1974824979 @default.
• W2890873042 cites W1974857747 @default.
• W2890873042 cites W1974982724 @default.
• W2890873042 cites W1975938392 @default.
• W2890873042 cites W1976752313 @default.
• W2890873042 cites W1976865584 @default.
• W2890873042 cites W1980228859 @default.
• W2890873042 cites W1980420785 @default.
• W2890873042 cites W1980977603 @default.
• W2890873042 cites W1981810931 @default.
• W2890873042 cites W1985024942 @default.
• W2890873042 cites W1985277235 @default.
• W2890873042 cites W1988791308 @default.
• W2890873042 cites W1991208841 @default.
• W2890873042 cites W1991798338 @default.
• W2890873042 cites W1992509051 @default.
• W2890873042 cites W1994115454 @default.
• W2890873042 cites W1995059505 @default.
• W2890873042 cites W1995478805 @default.
• W2890873042 cites W1995495792 @default.
• W2890873042 cites W1996001296 @default.
• W2890873042 cites W1996814078 @default.
• W2890873042 cites W1997059975 @default.
• W2890873042 cites W2001856136 @default.
• W2890873042 cites W2002213747 @default.
• W2890873042 cites W2002602431 @default.
• W2890873042 cites W2003338841 @default.
• W2890873042 cites W2006733352 @default.
• W2890873042 cites W2009259931 @default.
• W2890873042 cites W2014518719 @default.
• W2890873042 cites W2015167814 @default.
• W2890873042 cites W2015629481 @default.
• W2890873042 cites W2017108876 @default.
• W2890873042 cites W2019695510 @default.
• W2890873042 cites W2020433276 @default.
• W2890873042 cites W2020719892 @default.
• W2890873042 cites W2022674053 @default.
• W2890873042 cites W2023285758 @default.
• W2890873042 cites W2024622507 @default.
• W2890873042 cites W2026530415 @default.
• W2890873042 cites W2027603848 @default.
• W2890873042 cites W2028596588 @default.
• W2890873042 cites W2030851291 @default.
• W2890873042 cites W2033985997 @default.
• W2890873042 cites W2034368441 @default.
• W2890873042 cites W2038986435 @default.
• W2890873042 cites W2040742427 @default.
• W2890873042 cites W2042162774 @default.
• W2890873042 cites W2045728621 @default.
• W2890873042 cites W2049148428 @default.
• W2890873042 cites W2050264451 @default.
• W2890873042 cites W2054048077 @default.
• W2890873042 cites W2054700826 @default.
• W2890873042 cites W2054810445 @default.
• W2890873042 cites W2055583081 @default.
• W2890873042 cites W2057364502 @default.
• W2890873042 cites W2058667756 @default.
• W2890873042 cites W2059634474 @default.
• W2890873042 cites W2061192830 @default.
• W2890873042 cites W2064960897 @default.
• W2890873042 cites W2065978481 @default.
• W2890873042 cites W2070319469 @default.
• W2890873042 cites W2071243461 @default.
• W2890873042 cites W2071277983 @default.
• W2890873042 cites W2072177821 @default.
• W2890873042 cites W2072338505 @default.
• W2890873042 cites W2072956640 @default.
• W2890873042 cites W2075885094 @default.
• W2890873042 cites W2077535440 @default.

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