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- W2890877366 abstract "Abstract Cellular therapies designed to modulate or enhance immune responses are gaining acceptance as viable treatments for a variety of diseases, most notably in the oncology field. Some therapies such as granulocyte infusion have been a tool in transfusion medicine for more than 40 years, while novel therapies such as chimeric antigen receptor (CAR) T cells have only very recently been licensed for clinical use. This chapter will focus on T cell–based immunotherapy. Mechanistically, T-cell immune therapies range in function from replacing missing immune cells after chemotherapy (antiviral T-cell therapy), to augmenting or redirecting T-cell responses against tumors (tumor-infiltrating lymphocytes, or TILS, and CAR T cells), to modulating the systemic immune response in the case of regulatory T cells (Tregs). While the promise of T cell–based immune therapies is clear, the final determination of their benefit and the role transfusion medicine will play in providing these novel therapies is not defined and will depend on institutional resources and expertise." @default.
- W2890877366 created "2018-09-27" @default.
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- W2890877366 date "2019-01-01" @default.
- W2890877366 modified "2023-09-26" @default.
- W2890877366 title "T-Cell Immune Therapies" @default.
- W2890877366 doi "https://doi.org/10.1016/b978-0-12-813726-0.00087-8" @default.
- W2890877366 hasPublicationYear "2019" @default.
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