FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890877974> ?p ?o ?g. }

• W2890877974 endingPage "2808" @default.
• W2890877974 startingPage "2808" @default.
• W2890877974 abstract "Zearalenone hydrolase (ZHD) is the only reported α/β-hydrolase that can detoxify zearalenone (ZEN). ZHD has demonstrated its potential as a treatment for ZEN contamination that will not result in damage to cereal crops. Recent researches have shown that the V153H mutant ZHD increased the specific activity against α-ZOL, but decreased its specific activity to β-ZOL. To understand whyV153H mutation showed catalytic specificity for α-ZOL, four molecular dynamics simulations combining with protein network analysis for wild type ZHD α-ZOL, ZHD β-ZOL, V153H α-ZOL, and V153H β-ZOL complexes were performed using Gromacs software. Our theoretical results indicated that the V153H mutant could cause a conformational switch at the cap domain (residues Gly161–Thr190) to affect the relative position catalytic residue (H242). Protein network analysis illustrated that the V153H mutation enhanced the communication with the whole protein and residues with high betweenness in the four complexes, which were primarily assembled in the cap domain and residues Met241 to Tyr245 regions. In addition, the existence of α-ZOL binding to V153H mutation enlarged the distance from the OAE atom in α-ZOL to the NE2 atom in His242, which prompted the side chain of H242 to the position with catalytic activity, thereby increasing the activity of V153H on the α-ZOL. Furthermore, α-ZOL could easily form a right attack angle and attack distance in the ZHD and α-ZOL complex to guarantee catalytic reaction. The alanine scanning results indicated that modifications of the residues in the cap domain produced significant changes in the binding affinity for α-ZOL and β-ZOL. Our results may provide useful theoretical evidence for the mechanism underlying the catalytic specificity of ZHD." @default.
• W2890877974 created "2018-09-27" @default.
• W2890877974 creator A5001513345 @default.
• W2890877974 creator A5018742393 @default.
• W2890877974 creator A5021319454 @default.
• W2890877974 creator A5046334100 @default.
• W2890877974 creator A5052038915 @default.
• W2890877974 creator A5053734727 @default.
• W2890877974 creator A5074858754 @default.
• W2890877974 creator A5077107894 @default.
• W2890877974 date "2018-09-18" @default.
• W2890877974 modified "2023-10-16" @default.
• W2890877974 title "Theoretical Study on Zearalenol Compounds Binding with Wild Type Zearalenone Hydrolase and V153H Mutant" @default.
• W2890877974 cites W1984695931 @default.
• W2890877974 cites W1990939702 @default.
• W2890877974 cites W1992719189 @default.
• W2890877974 cites W2002033941 @default.
• W2890877974 cites W2005490060 @default.
• W2890877974 cites W2005756796 @default.
• W2890877974 cites W2007572995 @default.
• W2890877974 cites W2022615654 @default.
• W2890877974 cites W2023490488 @default.
• W2890877974 cites W2035266068 @default.
• W2890877974 cites W2059013803 @default.
• W2890877974 cites W2064225942 @default.
• W2890877974 cites W2067174909 @default.
• W2890877974 cites W2071728689 @default.
• W2890877974 cites W2077709135 @default.
• W2890877974 cites W2081693079 @default.
• W2890877974 cites W2090264443 @default.
• W2890877974 cites W2092387745 @default.
• W2890877974 cites W2096364354 @default.
• W2890877974 cites W2113707751 @default.
• W2890877974 cites W2114367386 @default.
• W2890877974 cites W2115503115 @default.
• W2890877974 cites W2170060741 @default.
• W2890877974 cites W2172194876 @default.
• W2890877974 cites W2328082223 @default.
• W2890877974 cites W2418701666 @default.
• W2890877974 cites W2463863946 @default.
• W2890877974 cites W2506497981 @default.
• W2890877974 cites W2528904040 @default.
• W2890877974 cites W2534688261 @default.
• W2890877974 cites W2560613547 @default.
• W2890877974 cites W2608649183 @default.
• W2890877974 cites W2626267122 @default.
• W2890877974 cites W2745473373 @default.
• W2890877974 cites W2756620943 @default.
• W2890877974 cites W2774548395 @default.
• W2890877974 cites W2785769442 @default.
• W2890877974 doi "https://doi.org/10.3390/ijms19092808" @default.
• W2890877974 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6165071" @default.
• W2890877974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30231501" @default.
• W2890877974 hasPublicationYear "2018" @default.
• W2890877974 type Work @default.
• W2890877974 sameAs 2890877974 @default.
• W2890877974 citedByCount "11" @default.
• W2890877974 countsByYear W28908779742019 @default.
• W2890877974 countsByYear W28908779742020 @default.
• W2890877974 countsByYear W28908779742022 @default.
• W2890877974 countsByYear W28908779742023 @default.
• W2890877974 crossrefType "journal-article" @default.
• W2890877974 hasAuthorship W2890877974A5001513345 @default.
• W2890877974 hasAuthorship W2890877974A5018742393 @default.
• W2890877974 hasAuthorship W2890877974A5021319454 @default.
• W2890877974 hasAuthorship W2890877974A5046334100 @default.
• W2890877974 hasAuthorship W2890877974A5052038915 @default.
• W2890877974 hasAuthorship W2890877974A5053734727 @default.
• W2890877974 hasAuthorship W2890877974A5074858754 @default.
• W2890877974 hasAuthorship W2890877974A5077107894 @default.
• W2890877974 hasBestOaLocation W28908779741 @default.
• W2890877974 hasConcept C104317684 @default.
• W2890877974 hasConcept C143065580 @default.
• W2890877974 hasConcept C145770059 @default.
• W2890877974 hasConcept C161790260 @default.
• W2890877974 hasConcept C181199279 @default.
• W2890877974 hasConcept C185592680 @default.
• W2890877974 hasConcept C207583985 @default.
• W2890877974 hasConcept C2777140777 @default.
• W2890877974 hasConcept C2779856020 @default.
• W2890877974 hasConcept C2780120296 @default.
• W2890877974 hasConcept C2781338088 @default.
• W2890877974 hasConcept C31903555 @default.
• W2890877974 hasConcept C41183919 @default.
• W2890877974 hasConcept C515207424 @default.
• W2890877974 hasConcept C55493867 @default.
• W2890877974 hasConcept C71240020 @default.
• W2890877974 hasConcept C84699730 @default.
• W2890877974 hasConceptScore W2890877974C104317684 @default.
• W2890877974 hasConceptScore W2890877974C143065580 @default.
• W2890877974 hasConceptScore W2890877974C145770059 @default.
• W2890877974 hasConceptScore W2890877974C161790260 @default.
• W2890877974 hasConceptScore W2890877974C181199279 @default.
• W2890877974 hasConceptScore W2890877974C185592680 @default.
• W2890877974 hasConceptScore W2890877974C207583985 @default.
• W2890877974 hasConceptScore W2890877974C2777140777 @default.
• W2890877974 hasConceptScore W2890877974C2779856020 @default.
• W2890877974 hasConceptScore W2890877974C2780120296 @default.

• next