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- W2890879517 abstract "Recent studies have provided evidence of associations between neurochemistry and reading (dis)ability (Pugh et al., 2014). Based on a long history of studies indicating that fluent reading entails the automatic convergence of the written and spoken forms of language and our recently proposed Neural Noise Hypothesis (Hancock et al., 2017), we hypothesized that individual differences in cross-modal integration would mediate, at least partially, the relationship between neurochemical concentrations and reading. Cross-modal integration was measured in 231 children using a two-alternative forced choice cross-modal matching task with three language conditions (letters, words, and pseudowords) and two levels of difficulty within each language condition. Neurometabolite concentrations of Choline (Cho), Glutamate (Glu), gamma-Aminobutyric (GABA), and N- acetyl-aspartate (NAA) were then measured in a subset of this sample (n=70) with Magnetic Resonance Spectroscopy (MRS). A structural equation mediation model revealed that the effect of cross-modal word matching mediated the relationship between increased Glu (which has been proposed to be an index of neural noise) and poorer reading ability. In addition, the effect of cross-modal word matching fully mediated a relationship between increased Cho and poorer reading ability. Multilevel mixed effects models confirmed that lower Cho predicted faster cross-modal matching reaction time, specifically in the hard word condition. These findings with Cho are consistent with previous work in both adults and children showing a negative associated between Cho and reading ability. We also found two novel neurochemical relationships with children’s cross-modal integration. Specifically, lower GABA and higher NAA predicted faster cross-modal matching reaction times. We interpret these results within a biochemical framework in which the ability of neurochemistry to predict reading ability may at least partially be explained by cross-modal integration." @default.
- W2890879517 created "2018-09-27" @default.
- W2890879517 creator A5011092750 @default.
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- W2890879517 creator A5087801331 @default.
- W2890879517 date "2018-09-04" @default.
- W2890879517 modified "2023-10-17" @default.
- W2890879517 title "Neurochemistry Predicts Convergence of Written and Spoken Language: A Proton Magnetic Resonance Spectroscopy Study of Cross-Modal Language Integration" @default.
- W2890879517 cites W1423823652 @default.
- W2890879517 cites W1545450687 @default.
- W2890879517 cites W1547906203 @default.
- W2890879517 cites W1638218062 @default.
- W2890879517 cites W181078315 @default.
- W2890879517 cites W1861267103 @default.
- W2890879517 cites W1913957972 @default.
- W2890879517 cites W1951724000 @default.
- W2890879517 cites W1969786859 @default.
- W2890879517 cites W1970397428 @default.
- W2890879517 cites W1971393847 @default.
- W2890879517 cites W1971440513 @default.
- W2890879517 cites W1974125904 @default.
- W2890879517 cites W1977248749 @default.
- W2890879517 cites W1977595281 @default.
- W2890879517 cites W1977633188 @default.
- W2890879517 cites W1978657121 @default.
- W2890879517 cites W1980182397 @default.
- W2890879517 cites W1990366495 @default.
- W2890879517 cites W1992720270 @default.
- W2890879517 cites W1992824062 @default.
- W2890879517 cites W1993083837 @default.
- W2890879517 cites W1993812365 @default.
- W2890879517 cites W2000278310 @default.
- W2890879517 cites W2001754026 @default.
- W2890879517 cites W2001954021 @default.
- W2890879517 cites W2005395201 @default.
- W2890879517 cites W2012140045 @default.
- W2890879517 cites W2012538216 @default.
- W2890879517 cites W2012747149 @default.
- W2890879517 cites W2017942640 @default.
- W2890879517 cites W2019088085 @default.
- W2890879517 cites W2025235974 @default.
- W2890879517 cites W2028394375 @default.
- W2890879517 cites W2036090074 @default.
- W2890879517 cites W2042400568 @default.
- W2890879517 cites W2047347093 @default.
- W2890879517 cites W2047421381 @default.
- W2890879517 cites W2048168580 @default.
- W2890879517 cites W2050740828 @default.
- W2890879517 cites W2054114455 @default.
- W2890879517 cites W2058014295 @default.
- W2890879517 cites W2062904486 @default.
- W2890879517 cites W2067800251 @default.
- W2890879517 cites W2071988309 @default.
- W2890879517 cites W2074932610 @default.
- W2890879517 cites W2075409453 @default.
- W2890879517 cites W2080423736 @default.
- W2890879517 cites W2081878981 @default.
- W2890879517 cites W2083133930 @default.
- W2890879517 cites W2083651237 @default.
- W2890879517 cites W2091287372 @default.
- W2890879517 cites W2092113950 @default.
- W2890879517 cites W2094447837 @default.
- W2890879517 cites W2096815642 @default.
- W2890879517 cites W2099580492 @default.
- W2890879517 cites W2102118295 @default.
- W2890879517 cites W2103366774 @default.
- W2890879517 cites W2105181886 @default.
- W2890879517 cites W2105632506 @default.
- W2890879517 cites W2107356982 @default.
- W2890879517 cites W2113153232 @default.
- W2890879517 cites W2119745801 @default.
- W2890879517 cites W2124245488 @default.
- W2890879517 cites W2125664909 @default.
- W2890879517 cites W2130933952 @default.
- W2890879517 cites W2130997052 @default.
- W2890879517 cites W2131785404 @default.
- W2890879517 cites W2131979841 @default.
- W2890879517 cites W2136056602 @default.
- W2890879517 cites W2138121810 @default.
- W2890879517 cites W2138229608 @default.
- W2890879517 cites W2138346266 @default.
- W2890879517 cites W2139806709 @default.
- W2890879517 cites W2144164305 @default.
- W2890879517 cites W2144710750 @default.
- W2890879517 cites W2144977059 @default.
- W2890879517 cites W2146991114 @default.
- W2890879517 cites W2147937797 @default.
- W2890879517 cites W2149470069 @default.
- W2890879517 cites W2153816902 @default.
- W2890879517 cites W2155214670 @default.
- W2890879517 cites W2157725061 @default.
- W2890879517 cites W2158388157 @default.
- W2890879517 cites W2159524209 @default.
- W2890879517 cites W2160547162 @default.