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- W2890882337 abstract "The Bcl-2 family of proteins serve as vital regulators in the intrinsic cell death pathway. Myeloid cell leukemia 1 (Mcl-1), a prosurvival member of the Bcl-2 family of proteins, is over-expressed in many tumor types. The over-expressed Mcl-1 protein promotes the formation and development of tumor and causes the resistance to several chemotherapeutic agents and Bcl-2/Bcl-x L inhibitors such as ABT-737 and ABT-199. Mcl-1 appears to be a promising cancer target as important as other Bcl-2 anti-apoptotic proteins. Encouragingly, last half-decade has witnessed a rapid surge of interest towards the discovery of Mcl-1 inhibitors. This review highlighted the recent progress of Mcl-1 inhibitors." @default.
- W2890882337 created "2018-09-27" @default.
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- W2890882337 date "2015-09-01" @default.
- W2890882337 modified "2023-10-18" @default.
- W2890882337 title "Progress on Mcl-1 small molecule inhibitors" @default.
- W2890882337 doi "https://doi.org/10.1360/n032015-00113" @default.
- W2890882337 hasPublicationYear "2015" @default.
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