FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890882534> ?p ?o ?g. }

• W2890882534 abstract "Activation of the T cell receptor (TCR) on the T cell through ligation with antigen-MHC complex of an antigen-presenting cell (APC) is an essential process in the activation of T cells and induction of the subsequent adaptive immune response. Upon activation, the TCR, together with its associated co-receptor CD3 complex, assembles in signaling microclusters that are transported to the center of the organizational structure at the T cell-APC interface termed the immunological synapse (IS). During IS formation, local cell surface receptors and associated intracellular molecules are reorganized, ultimately creating the typical bull's eye-shaped pattern of the IS. CD6 is a surface glycoprotein receptor, which has been previously shown to associate with CD3 and co-localize to the center of the IS in static conditions or stable T cell-APC contacts. In this study, we report the use of different experimental set-ups analyzed with microscopy techniques to study the dynamics and stability of CD6-TCR/CD3 interaction dynamics and stability during IS formation in more detail. We exploited antibody spots, created with microcontact printing, and antibody-coated beads, and could demonstrate that CD6 and the TCR/CD3 complex co-localize and are recruited into a stimulatory cluster on the cell surface of T cells. Furthermore, we demonstrate, for the first time, that CD6 forms microclusters co-localizing with TCR/CD3 microclusters during IS formation on supported lipid bilayers. These co-localizing CD6 and TCR/CD3 microclusters are both radially transported toward the center of the IS formed in T cells, in an actin polymerization-dependent manner. Overall, our findings further substantiate the role of CD6 during IS formation and provide novel insight into the dynamic properties of this CD6-TCR/CD3 complex interplay. From a methodological point of view, the biophysical approaches used to characterize these receptors are complementary and amenable for investigation of the dynamic interactions of other membrane receptors." @default.
• W2890882534 created "2018-09-27" @default.
• W2890882534 creator A5026129752 @default.
• W2890882534 creator A5041824888 @default.
• W2890882534 creator A5042093676 @default.
• W2890882534 creator A5044250966 @default.
• W2890882534 creator A5045102938 @default.
• W2890882534 creator A5052126051 @default.
• W2890882534 creator A5054940822 @default.
• W2890882534 creator A5062996053 @default.
• W2890882534 creator A5063373289 @default.
• W2890882534 creator A5079439604 @default.
• W2890882534 date "2018-10-09" @default.
• W2890882534 modified "2023-10-03" @default.
• W2890882534 title "Biophysical Characterization of CD6—TCR/CD3 Interplay in T Cells" @default.
• W2890882534 cites W1551156675 @default.
• W2890882534 cites W1562116524 @default.
• W2890882534 cites W1562441478 @default.
• W2890882534 cites W1594159197 @default.
• W2890882534 cites W1603627149 @default.
• W2890882534 cites W1631781682 @default.
• W2890882534 cites W1968272833 @default.
• W2890882534 cites W1974374103 @default.
• W2890882534 cites W1975475966 @default.
• W2890882534 cites W1977508422 @default.
• W2890882534 cites W1981565131 @default.
• W2890882534 cites W1990369819 @default.
• W2890882534 cites W2017934591 @default.
• W2890882534 cites W2022532491 @default.
• W2890882534 cites W2023744705 @default.
• W2890882534 cites W2035469701 @default.
• W2890882534 cites W2042342193 @default.
• W2890882534 cites W2046206523 @default.
• W2890882534 cites W2046287534 @default.
• W2890882534 cites W2052249831 @default.
• W2890882534 cites W2056204193 @default.
• W2890882534 cites W2057024012 @default.
• W2890882534 cites W2066019586 @default.
• W2890882534 cites W2066668926 @default.
• W2890882534 cites W2069308992 @default.
• W2890882534 cites W2069886676 @default.
• W2890882534 cites W2070011436 @default.
• W2890882534 cites W2070495940 @default.
• W2890882534 cites W2075723649 @default.
• W2890882534 cites W2078642388 @default.
• W2890882534 cites W2079543912 @default.
• W2890882534 cites W2081367737 @default.
• W2890882534 cites W2083483039 @default.
• W2890882534 cites W2084388859 @default.
• W2890882534 cites W2096234619 @default.
• W2890882534 cites W2098882468 @default.
• W2890882534 cites W2101433730 @default.
• W2890882534 cites W2104123450 @default.
• W2890882534 cites W2104814628 @default.
• W2890882534 cites W2115294635 @default.
• W2890882534 cites W2124733101 @default.
• W2890882534 cites W2126873850 @default.
• W2890882534 cites W2127424425 @default.
• W2890882534 cites W2130779526 @default.
• W2890882534 cites W2131537135 @default.
• W2890882534 cites W2135630804 @default.
• W2890882534 cites W2138197182 @default.
• W2890882534 cites W2139970775 @default.
• W2890882534 cites W2141826840 @default.
• W2890882534 cites W2142685018 @default.
• W2890882534 cites W2143600483 @default.
• W2890882534 cites W2144588996 @default.
• W2890882534 cites W2147971828 @default.
• W2890882534 cites W2153858489 @default.
• W2890882534 cites W2160639454 @default.
• W2890882534 cites W2167279371 @default.
• W2890882534 cites W2219093167 @default.
• W2890882534 cites W2261187491 @default.
• W2890882534 cites W2322378610 @default.
• W2890882534 cites W2465444305 @default.
• W2890882534 cites W2559464872 @default.
• W2890882534 cites W2568482147 @default.
• W2890882534 cites W2588692501 @default.
• W2890882534 cites W2609595776 @default.
• W2890882534 cites W2740862211 @default.
• W2890882534 cites W2777469091 @default.
• W2890882534 cites W2792693713 @default.
• W2890882534 doi "https://doi.org/10.3389/fimmu.2018.02333" @default.
• W2890882534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6189472" @default.
• W2890882534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30356797" @default.
• W2890882534 hasPublicationYear "2018" @default.
• W2890882534 type Work @default.
• W2890882534 sameAs 2890882534 @default.
• W2890882534 citedByCount "11" @default.
• W2890882534 countsByYear W28908825342018 @default.
• W2890882534 countsByYear W28908825342019 @default.
• W2890882534 countsByYear W28908825342020 @default.
• W2890882534 countsByYear W28908825342021 @default.
• W2890882534 countsByYear W28908825342022 @default.
• W2890882534 crossrefType "journal-article" @default.
• W2890882534 hasAuthorship W2890882534A5026129752 @default.
• W2890882534 hasAuthorship W2890882534A5041824888 @default.
• W2890882534 hasAuthorship W2890882534A5042093676 @default.
• W2890882534 hasAuthorship W2890882534A5044250966 @default.
• W2890882534 hasAuthorship W2890882534A5045102938 @default.

• next