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• W2890883556 abstract "Inhibition is considered to shape neural activity, and broaden its pattern repertoire. In the sensory organs, where the anatomy of neural circuits is highly structured, lateral inhibition sharpens contrast among stimulus properties. The impact of inhibition on stimulus processing and the involvement of lateral inhibition is less clear when activity propagates to the less-structured relay stations. Here we take a synthetic approach to disentangle the impacts of inhibition from that of specialized anatomy on the repertoire of evoked activity patterns, and as a result, the network capacity to uniquely represent different stimuli. To this aim, we blocked inhibition in randomly rewired networks of cortical neurons in-vitro, and quantified response variability and stimulus discrimination among stimuli provided at different spatial loci, before and after the blockade. We show that blocking inhibition quenches variability of responses evoked by repeated stimuli through any spatial source; for all tested response features. Despite the sharpening role of inhibition in the highly structured sensory organs, in these random networks we find that blocking inhibition enhances stimulus discrimination between spatial sources of stimulation, when based on response features that emphasize the relation among spike times recorded through different electrodes. We further show that under intact inhibition, responses to a given stimulus are a noisy version of those revealed by blocking inhibition; such that intact inhibition disrupts an otherwise coherent, wave propagation of activity." @default.
• W2890883556 created "2018-09-27" @default.
• W2890883556 creator A5019425602 @default.
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• W2890883556 date "2018-09-15" @default.
• W2890883556 modified "2023-09-27" @default.
• W2890883556 title "Inhibition in Random Neuronal Networks Enhances Response Variability and Disrupts Stimulus Discrimination" @default.
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