FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890884484> ?p ?o ?g. }

• W2890884484 abstract "Abstract Background In subcutaneous adipose tissue (SAT), higher stearoyl-CoA desaturase-1 ( SCD1 ) expression has been related to improved insulin sensitivity in thiazolidinedione-treated type 2 diabetes mellitus patients. In animal models, deficiency of the free fatty acid receptor ( FFAR ) 2 associated with higher and FFAR4 -deficiency with lower insulin sensitivity. We hypothesized that increased FFAR2 expression and reductions in FFAR4 and SCD1 expression in SAT of type 2 diabetes mellitus patients associate positively with insulin resistance and impaired beta cell function. Methods Twenty-five type 2 diabetes mellitus patients and 25 glucose-tolerant humans (CON) matched for sex, age, and BMI underwent mixed-meal tests to assess insulin sensitivity (OGIS) and beta cell function (ΔAUC(C-peptide) 0–180 min /ΔAUC(glucose) 0–180 min ) in a cross-sectional study. Gene and protein expression of SCD1 and FFAR2/4 were quantified in SAT biopsies. Results Insulin sensitivity was 14% and beta cell function 71% (both p < 0.001) lower in type 2 diabetes mellitus patients. In type 2 diabetes mellitus, SCD1 mRNA was fivefold ( p < 0.001) and protein expression twofold ( p < 0.01) lower. While FFAR2/4 mRNA and protein expression did not differ between groups, FFAR2 protein levels correlated negatively with beta cell function only in CON ( r = −0.74, p < 0.01). However, neither SCD1 nor FFAR2/4 protein expression correlated with insulin sensitivity in both groups. Conclusions Type 2 diabetes patients have lower SCD1, which does not associate with insulin resistance. Only in non-diabetic humans, FFAR2 associated with impaired beta cell function." @default.
• W2890884484 created "2018-09-27" @default.
• W2890884484 creator A5019985913 @default.
• W2890884484 creator A5020607761 @default.
• W2890884484 creator A5022032933 @default.
• W2890884484 creator A5022174704 @default.
• W2890884484 creator A5026182370 @default.
• W2890884484 creator A5028446880 @default.
• W2890884484 creator A5030852020 @default.
• W2890884484 creator A5036247938 @default.
• W2890884484 creator A5044574961 @default.
• W2890884484 creator A5046010815 @default.
• W2890884484 creator A5064733533 @default.
• W2890884484 creator A5066435946 @default.
• W2890884484 creator A5066784308 @default.
• W2890884484 date "2018-09-07" @default.
• W2890884484 modified "2023-10-14" @default.
• W2890884484 title "Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus" @default.
• W2890884484 cites W1598254642 @default.
• W2890884484 cites W1964921050 @default.
• W2890884484 cites W1975037124 @default.
• W2890884484 cites W2008114808 @default.
• W2890884484 cites W2014901805 @default.
• W2890884484 cites W2020275122 @default.
• W2890884484 cites W2032919742 @default.
• W2890884484 cites W2037921130 @default.
• W2890884484 cites W2053307994 @default.
• W2890884484 cites W2059842910 @default.
• W2890884484 cites W2064428756 @default.
• W2890884484 cites W2076128586 @default.
• W2890884484 cites W2076511407 @default.
• W2890884484 cites W2080549540 @default.
• W2890884484 cites W2081652010 @default.
• W2890884484 cites W2092441434 @default.
• W2890884484 cites W2110526875 @default.
• W2890884484 cites W2112011183 @default.
• W2890884484 cites W2118174270 @default.
• W2890884484 cites W2120952251 @default.
• W2890884484 cites W2127197277 @default.
• W2890884484 cites W2127277443 @default.
• W2890884484 cites W2129891937 @default.
• W2890884484 cites W2131094572 @default.
• W2890884484 cites W2135902632 @default.
• W2890884484 cites W2136014653 @default.
• W2890884484 cites W2141610820 @default.
• W2890884484 cites W2144509989 @default.
• W2890884484 cites W2148095099 @default.
• W2890884484 cites W2163157908 @default.
• W2890884484 cites W2165447879 @default.
• W2890884484 cites W2165476589 @default.
• W2890884484 cites W2166568789 @default.
• W2890884484 cites W2169294908 @default.
• W2890884484 cites W2171988255 @default.
• W2890884484 cites W2302624537 @default.
• W2890884484 cites W2302718753 @default.
• W2890884484 cites W2318598002 @default.
• W2890884484 cites W2410539253 @default.
• W2890884484 cites W2803322171 @default.
• W2890884484 cites W4205321574 @default.
• W2890884484 doi "https://doi.org/10.1038/s41387-018-0054-9" @default.
• W2890884484 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6127327" @default.
• W2890884484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30190473" @default.
• W2890884484 hasPublicationYear "2018" @default.
• W2890884484 type Work @default.
• W2890884484 sameAs 2890884484 @default.
• W2890884484 citedByCount "12" @default.
• W2890884484 countsByYear W28908844842019 @default.
• W2890884484 countsByYear W28908844842020 @default.
• W2890884484 countsByYear W28908844842021 @default.
• W2890884484 countsByYear W28908844842023 @default.
• W2890884484 crossrefType "journal-article" @default.
• W2890884484 hasAuthorship W2890884484A5019985913 @default.
• W2890884484 hasAuthorship W2890884484A5020607761 @default.
• W2890884484 hasAuthorship W2890884484A5022032933 @default.
• W2890884484 hasAuthorship W2890884484A5022174704 @default.
• W2890884484 hasAuthorship W2890884484A5026182370 @default.
• W2890884484 hasAuthorship W2890884484A5028446880 @default.
• W2890884484 hasAuthorship W2890884484A5030852020 @default.
• W2890884484 hasAuthorship W2890884484A5036247938 @default.
• W2890884484 hasAuthorship W2890884484A5044574961 @default.
• W2890884484 hasAuthorship W2890884484A5046010815 @default.
• W2890884484 hasAuthorship W2890884484A5064733533 @default.
• W2890884484 hasAuthorship W2890884484A5066435946 @default.
• W2890884484 hasAuthorship W2890884484A5066784308 @default.
• W2890884484 hasBestOaLocation W28908844841 @default.
• W2890884484 hasConcept C126322002 @default.
• W2890884484 hasConcept C134018914 @default.
• W2890884484 hasConcept C165220095 @default.
• W2890884484 hasConcept C171089720 @default.
• W2890884484 hasConcept C2776828364 @default.
• W2890884484 hasConcept C2777180221 @default.
• W2890884484 hasConcept C2777391703 @default.
• W2890884484 hasConcept C2779306644 @default.
• W2890884484 hasConcept C2781232474 @default.
• W2890884484 hasConcept C2910068830 @default.
• W2890884484 hasConcept C555293320 @default.
• W2890884484 hasConcept C71924100 @default.
• W2890884484 hasConceptScore W2890884484C126322002 @default.
• W2890884484 hasConceptScore W2890884484C134018914 @default.
• W2890884484 hasConceptScore W2890884484C165220095 @default.

• next