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- W2890885168 abstract "Background: Although there is evidence that suboptimal reperfusion has short-term prognostic impact in patients with STsegmentelevation acute coronary syndromes, there is little information about its associated factors.Objectives: The aim of this study was to analyze the factors associated with suboptimal reperfusion in patients with acuteST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI).Methods: Patients from the SCAR (Acute Coronary Syndromes in Argentina) registry diagnosed with acute STEMI undergoingPCI were included in the study. The association of classical clinical and laboratory variables and the leuko-glycemic indexwith suboptimal reperfusion was analyzed. Suboptimal reperfusion was defined as post-PCI angiography TIMI III flow withless than 50% ST-segment decrease in the ECG.Results: Overall, 197 patients (76.4%) out of 258 patients with acute STEMI met the inclusion criteria. Among them, 8.6%(n: 17) had suboptimal reperfusion, with an incidence of in-hospital death of 17.6% (n: 3) versus 1.7% (n: 3) in patients withoutsuboptimal reperfusion (p=0.007). In the univariate analysis, variables associated with suboptimal reperfusion were: diabetes[OR: 3.2 (1.09-9.43) p=0.026], previous revascularization [OR: 5.8 (1.74-19.07) p=0.008], leuko-glycemic index (> 2,159) [OR3.7 (1.32-10.22) p=0.009], and pain-to-balloon time (>159 minutes) [OR: 6.9 (0.88- 53) p=0.045]. Age >70 years, male sex,high blood pressure, smoking, previous or anterior-wall infarction, and Killip and Kimball 3-4 and TIMI 0-1 flow on admissionwere not significantly different between patients with or without suboptimal reperfusion. Prior to the analysis, the cutoff pointfor the leuko-glycemic index associated with suboptimal reperfusion was established at 2,159 points by ROC curve analysis(NPV: 94%), and the pain-to-balloon time at 159 min (NPV: 96%). In logistic regression analysis, only previous revascularization[OR: 5.3 (1.53 -18.55)] and leuko-glycemic index [OR: 3.2 (1.11-9.28)] were associated with suboptimal reperfusion." @default.
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- W2890885168 date "2018-07-16" @default.
- W2890885168 modified "2023-09-23" @default.
- W2890885168 title "Suboptimal Reperfusion in Patients with ST-Segment Elevation Acute Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention: Predictors and Prognostic Value" @default.
- W2890885168 doi "https://doi.org/10.7775/ajc.86.4.13325" @default.
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