Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890885753> ?p ?o ?g. }
- W2890885753 endingPage "2354" @default.
- W2890885753 startingPage "2354" @default.
- W2890885753 abstract "Keeping in mind the concept of green chemistry, this research aims to synthesize and characterize new ionic liquids (ILs) derived from N-cinnamyl imidazole with different sizes of alkyl chains (1, 6, 8, and 10 carbon atoms), and evaluate their antibacterial activity against Skin and soft tissue infections (SSTIs) causative bacteria. The antibacterial screening was carried out by agar well diffusion and the Minimum Inhibitory Concentration (MIC) and Half Maximum Inhibitory Concentration (IC50) of the different ILs were determined by microdilution in broth, also Molecular dynamics simulations were performed to study the interaction mechanism between ILs and membranes. The MIC value in Gram-positive bacteria showed that as the hydrocarbon chain increases, the MIC value decreases with a dose-dependent effect. Furthermore, Gram-negative bacteria showed high MIC values, which were also evidenced in the antibacterial screening. The molecular dynamics showed an incorporation of the ILs with the longer chain (10 C), corresponding to a passive diffusion towards the membrane surface, for its part, the ILs with the shorter chain due to its lack of hydrophobicity was not incorporated into the bilayer. Finally, the new ILs synthesized could be an alternative for the treatment of Gram-positive bacteria causative of SSTIs." @default.
- W2890885753 created "2018-09-27" @default.
- W2890885753 creator A5013698551 @default.
- W2890885753 creator A5017074064 @default.
- W2890885753 creator A5019322204 @default.
- W2890885753 creator A5046962908 @default.
- W2890885753 creator A5085392174 @default.
- W2890885753 creator A5085510953 @default.
- W2890885753 creator A5086227676 @default.
- W2890885753 date "2018-09-14" @default.
- W2890885753 modified "2023-10-03" @default.
- W2890885753 title "Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections" @default.
- W2890885753 cites W1805953322 @default.
- W2890885753 cites W1856107719 @default.
- W2890885753 cites W1874122563 @default.
- W2890885753 cites W1969401195 @default.
- W2890885753 cites W1985648308 @default.
- W2890885753 cites W1996858800 @default.
- W2890885753 cites W1997772366 @default.
- W2890885753 cites W1998765981 @default.
- W2890885753 cites W1999619490 @default.
- W2890885753 cites W2001702281 @default.
- W2890885753 cites W2011805435 @default.
- W2890885753 cites W2015260854 @default.
- W2890885753 cites W2015884448 @default.
- W2890885753 cites W2028702957 @default.
- W2890885753 cites W2029667189 @default.
- W2890885753 cites W2043840206 @default.
- W2890885753 cites W2048829417 @default.
- W2890885753 cites W2052665036 @default.
- W2890885753 cites W2067492598 @default.
- W2890885753 cites W2070558122 @default.
- W2890885753 cites W2070753604 @default.
- W2890885753 cites W2079011550 @default.
- W2890885753 cites W2089440726 @default.
- W2890885753 cites W2103207805 @default.
- W2890885753 cites W2105641988 @default.
- W2890885753 cites W2135732933 @default.
- W2890885753 cites W2137423431 @default.
- W2890885753 cites W2141235909 @default.
- W2890885753 cites W2146873065 @default.
- W2890885753 cites W2150981663 @default.
- W2890885753 cites W2157388335 @default.
- W2890885753 cites W2179024255 @default.
- W2890885753 cites W2190917552 @default.
- W2890885753 cites W2217315960 @default.
- W2890885753 cites W2290970559 @default.
- W2890885753 cites W2364044060 @default.
- W2890885753 cites W2396269110 @default.
- W2890885753 cites W2431612173 @default.
- W2890885753 cites W2443792889 @default.
- W2890885753 cites W2490869902 @default.
- W2890885753 cites W2528193427 @default.
- W2890885753 cites W2592874021 @default.
- W2890885753 cites W2603039590 @default.
- W2890885753 cites W2610609138 @default.
- W2890885753 cites W2767744343 @default.
- W2890885753 cites W2800239995 @default.
- W2890885753 cites W2810253416 @default.
- W2890885753 cites W4252881903 @default.
- W2890885753 cites W4376453134 @default.
- W2890885753 doi "https://doi.org/10.3390/molecules23092354" @default.
- W2890885753 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6225289" @default.
- W2890885753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30223457" @default.
- W2890885753 hasPublicationYear "2018" @default.
- W2890885753 type Work @default.
- W2890885753 sameAs 2890885753 @default.
- W2890885753 citedByCount "40" @default.
- W2890885753 countsByYear W28908857532019 @default.
- W2890885753 countsByYear W28908857532020 @default.
- W2890885753 countsByYear W28908857532021 @default.
- W2890885753 countsByYear W28908857532022 @default.
- W2890885753 countsByYear W28908857532023 @default.
- W2890885753 crossrefType "journal-article" @default.
- W2890885753 hasAuthorship W2890885753A5013698551 @default.
- W2890885753 hasAuthorship W2890885753A5017074064 @default.
- W2890885753 hasAuthorship W2890885753A5019322204 @default.
- W2890885753 hasAuthorship W2890885753A5046962908 @default.
- W2890885753 hasAuthorship W2890885753A5085392174 @default.
- W2890885753 hasAuthorship W2890885753A5085510953 @default.
- W2890885753 hasAuthorship W2890885753A5086227676 @default.
- W2890885753 hasBestOaLocation W28908857531 @default.
- W2890885753 hasConcept C11636898 @default.
- W2890885753 hasConcept C154881586 @default.
- W2890885753 hasConcept C161790260 @default.
- W2890885753 hasConcept C176947019 @default.
- W2890885753 hasConcept C178790620 @default.
- W2890885753 hasConcept C185592680 @default.
- W2890885753 hasConcept C2780104969 @default.
- W2890885753 hasConcept C41625074 @default.
- W2890885753 hasConcept C4937899 @default.
- W2890885753 hasConcept C523546767 @default.
- W2890885753 hasConcept C54355233 @default.
- W2890885753 hasConcept C55493867 @default.
- W2890885753 hasConcept C86803240 @default.
- W2890885753 hasConcept C89423630 @default.
- W2890885753 hasConceptScore W2890885753C11636898 @default.
- W2890885753 hasConceptScore W2890885753C154881586 @default.