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- W2890886592 abstract "In this work, we developed a catalyst-free amination of 2-mercaptobenzoxazoles on water under microwave irradiation. The product, 2-aminobenzoxazoles, was successfully produced via direct amination with various amines in moderate to high yields. The formal synthesis of Suvorexant, a medication for the treatment of insomnia, was accomplished using a developed amination process. The reaction was completed in an hour at 100–150 °C in a microwave reactor without the use of external catalyst or additive. Key benefits of this process include an on-water reaction, short reaction time, being scalable and catalyst-free, and use of 2-mercaptobenzoxazoles as an inexpensive starting material having low environmental impact in its preparation." @default.
- W2890886592 created "2018-09-27" @default.
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- W2890886592 date "2018-09-07" @default.
- W2890886592 modified "2023-10-17" @default.
- W2890886592 title "Microwave-Enhanced On-Water Amination of 2-Mercaptobenzoxazoles To Prepare 2-Aminobenzoxazoles" @default.
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- W2890886592 doi "https://doi.org/10.1021/acs.joc.8b01824" @default.
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