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- W2890886772 abstract "Introduction: The prognosis of pancreatic adenocarcinoma (PAC) remains poor even after better surgical and perioperative care. Objective: To identify factors associated with better survival in patients with PAC treated with pancreaticoduodenectomy (PDD) at our institution. Methods: Case-control study of PAC patients treated with PDD at our Hospital between January 2002 and December 2015. For statistical analysis, we compared the patients surviving more than 36 months after the operation, to the ones who did not reach this period. Biodemographic, clinical, histopathological and morbimortality data were compared between cases and controls using logistic regression. Results: Seventy patients were analyzed; mean age of 62, ± 11 years; 40 (57%) women. Mean and overall survival was 34 months and 22% at five years for the entire series. Mean resected lymph nodes was 18 ± 9. Twenty-one cases (30%) reached a survival greater than 36 months. At univariate analysis, R0 resection, the absence of positive lymph nodes, the absence of perineural infiltration and early stages (IA, IB and IIA) were associated with survival greater than 36 months (p < 0,05). After multivariable analysis, the absence of diabetes mellitus at the time of diagnosis (OR:12, 95% CI 1.7–84.3); the absence of perineural infiltration (OR: 7, 95% CI 1.3–36.3) and early stages (OR: 10, 05% CI 2.1–49.1) were demonstrated to be independent factors associated with survival greater than three years. Conclusion: Early stages of the disease, the absence of diabetes mellitus and no perineural infiltration at specimen were associated with survival greater than three years." @default.
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- W2890886772 date "2018-09-01" @default.
- W2890886772 modified "2023-10-16" @default.
- W2890886772 title "Factors associated with better survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma" @default.
- W2890886772 doi "https://doi.org/10.1016/j.hpb.2018.06.2333" @default.
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