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- W2890888750 abstract "Abstract Exosomes are cell‐derived vesicles that have been implicated in the pathogenesis of many inflammatory diseases. More specifically, it has been shown that T cell‐derived exosomes can induce immunological responses; however, little is known about the mechanism and the molecular content of these vesicles. Here, we used a proteomic approach to characterize human T cell‐derived exosomes. We found that specific proteins of the RAS signaling pathway were enriched in exosomes derived from activated T cells, and that these vesicles induced ERK phosphorylation in recipient immune cells. Our findings support a mechanistic role of exosomes in cellular activation, and further studies should consider exosomes as a biomarker for inflammatory diseases." @default.
- W2890888750 created "2018-09-27" @default.
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- W2890888750 date "2018-10-03" @default.
- W2890888750 modified "2023-10-16" @default.
- W2890888750 title "Proteomic analysis of human T cell‐derived exosomes reveals differential RAS/MAPK signaling" @default.
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- W2890888750 doi "https://doi.org/10.1002/eji.201847655" @default.
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