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- W2890890014 abstract "Micelles assembled from amphiphilic molecules have proved to be ideal scaffolds to construct artificial catalysts mimicking enzymatic catalytic behavior. In this paper, we describe the synthesis of amphiphilic poly(2-oxazoline) derivatives with l-prolinamide units in the side chain and their application in asymmetric aldol reactions. Upon dissolution in water, the pseudopeptide polymers self-assembled into particles with different sizes, relying on the copolymer composition and distribution of hydrophilic/hydrophobic segments in the polymer chain. A preliminary study has demonstrated that the catalytic activity of these polymeric organocatalysts are strongly dependent on the aggregated architecture. The micelle-type assemblies can act as nanoreactors to efficiently promote the direct aldolisation of cyclohexanone with aromatic aldehydes in aqueous media, affording anti-aldol products in excellent yields (88–99%) and higher stereoselectivities (90/10 dr, 86% ee) compared to their nonmicellar systems under identical conditions." @default.
- W2890890014 created "2018-09-27" @default.
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- W2890890014 date "2018-09-10" @default.
- W2890890014 modified "2023-10-15" @default.
- W2890890014 title "A Pseudopeptide Polymer Micelle Used for Asymmetric Catalysis of the Aldol Reaction in Water" @default.
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- W2890890014 doi "https://doi.org/10.3390/polym10091004" @default.
- W2890890014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6403597" @default.
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