FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890891458> ?p ?o ?g. }

• W2890891458 endingPage "e5539" @default.
• W2890891458 startingPage "e5539" @default.
• W2890891458 abstract "Background Autonomic dysfunction (AD) is one of the non-motor features of Parkinson’s disease (PD). Some symptoms tend to occur in the early stages of PD. AD also has a great impact on patient’s quality of life. In this study, we aimed to discover the association between AD (Scales for Outcomes in Parkinson’s disease-Autonomic, SCOPA-AUT) and microstructural changes in white matter tracts in drug-naïve early PD patients to elucidate the central effects of autonomic nervous system impairments. Method In total, this study included 85 subjects with PD recruited from the Parkinson’s Progression Markers Initiative (PPMI) database. Among the 85 PD patients, 38 were in Hoehn & Yahr stage 1 (HY1PD) and 47 were in stage 2 (HY2PD). Diffusion magnetic resonance imaging (DMRI) data were reconstructed in the MNI space using q-space diffeomorphic reconstruction to obtain the spin distribution function. The spin distribution function (SDF) values were used in DMRI connectometry analysis. We investigated through diffusion MRI connectometry the structural correlates of white matter tracts with SCOPA-AUT subscores and total score. Results Connectometry analysis also revealed positive association with white matter density in bilateral corticospinal tract in HY1PD patients and negative association in genu of corpus callosum (CC) and, bilateral cingulum in both groups. In addition, there were associations between gastrointestinal, sexual, thermoregulatory and urinary items and structural brain connectivity in PD. Conclusion Our study reveals positive correlation, suggesting neural compensations in early PD. Cingulum and CC tracts have well-known roles in PD pathology, compatible with our findings that bring new insights to specific areas of AD and its role in central nervous system (CNS) neurodegeneration, paving the way for using prodromal makers in the diagnosis and treatment of PD." @default.
• W2890891458 created "2018-09-27" @default.
• W2890891458 creator A5030768137 @default.
• W2890891458 creator A5041271787 @default.
• W2890891458 creator A5044110862 @default.
• W2890891458 creator A5068772116 @default.
• W2890891458 date "2018-09-13" @default.
• W2890891458 modified "2023-10-14" @default.
• W2890891458 title "Autonomic dysfunction and white matter microstructural changes in drug-naïve patients with Parkinson’s disease" @default.
• W2890891458 cites W1440913109 @default.
• W2890891458 cites W1557133730 @default.
• W2890891458 cites W1598029032 @default.
• W2890891458 cites W1897400833 @default.
• W2890891458 cites W1964802316 @default.
• W2890891458 cites W1970214734 @default.
• W2890891458 cites W1976968148 @default.
• W2890891458 cites W1982535961 @default.
• W2890891458 cites W1985124458 @default.
• W2890891458 cites W1988494453 @default.
• W2890891458 cites W2006905206 @default.
• W2890891458 cites W2011030038 @default.
• W2890891458 cites W2016957922 @default.
• W2890891458 cites W2017726976 @default.
• W2890891458 cites W2039748355 @default.
• W2890891458 cites W2043866939 @default.
• W2890891458 cites W2044752682 @default.
• W2890891458 cites W2046189898 @default.
• W2890891458 cites W2057368557 @default.
• W2890891458 cites W2066809905 @default.
• W2890891458 cites W2075105217 @default.
• W2890891458 cites W2084357246 @default.
• W2890891458 cites W2094529877 @default.
• W2890891458 cites W2096788173 @default.
• W2890891458 cites W2101697102 @default.
• W2890891458 cites W2103939473 @default.
• W2890891458 cites W2112863940 @default.
• W2890891458 cites W2132310402 @default.
• W2890891458 cites W2137918406 @default.
• W2890891458 cites W2138850552 @default.
• W2890891458 cites W2146210116 @default.
• W2890891458 cites W2151854373 @default.
• W2890891458 cites W2156411508 @default.
• W2890891458 cites W2162234212 @default.
• W2890891458 cites W2165976376 @default.
• W2890891458 cites W2178019869 @default.
• W2890891458 cites W2181004835 @default.
• W2890891458 cites W2195542124 @default.
• W2890891458 cites W2276299450 @default.
• W2890891458 cites W2525795464 @default.
• W2890891458 cites W2539068846 @default.
• W2890891458 cites W2539957110 @default.
• W2890891458 cites W2541459940 @default.
• W2890891458 cites W2551286621 @default.
• W2890891458 cites W2552140126 @default.
• W2890891458 cites W2586235369 @default.
• W2890891458 cites W2737550467 @default.
• W2890891458 cites W2778855371 @default.
• W2890891458 cites W2781877724 @default.
• W2890891458 cites W2918263135 @default.
• W2890891458 cites W4213459747 @default.
• W2890891458 doi "https://doi.org/10.7717/peerj.5539" @default.
• W2890891458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6139241" @default.
• W2890891458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30225168" @default.
• W2890891458 hasPublicationYear "2018" @default.
• W2890891458 type Work @default.
• W2890891458 sameAs 2890891458 @default.
• W2890891458 citedByCount "12" @default.
• W2890891458 countsByYear W28908914582018 @default.
• W2890891458 countsByYear W28908914582020 @default.
• W2890891458 countsByYear W28908914582021 @default.
• W2890891458 countsByYear W28908914582022 @default.
• W2890891458 countsByYear W28908914582023 @default.
• W2890891458 crossrefType "journal-article" @default.
• W2890891458 hasAuthorship W2890891458A5030768137 @default.
• W2890891458 hasAuthorship W2890891458A5041271787 @default.
• W2890891458 hasAuthorship W2890891458A5044110862 @default.
• W2890891458 hasAuthorship W2890891458A5068772116 @default.
• W2890891458 hasBestOaLocation W28908914581 @default.
• W2890891458 hasConcept C126322002 @default.
• W2890891458 hasConcept C126838900 @default.
• W2890891458 hasConcept C142724271 @default.
• W2890891458 hasConcept C143409427 @default.
• W2890891458 hasConcept C143998085 @default.
• W2890891458 hasConcept C149550507 @default.
• W2890891458 hasConcept C15744967 @default.
• W2890891458 hasConcept C164705383 @default.
• W2890891458 hasConcept C169760540 @default.
• W2890891458 hasConcept C2777193593 @default.
• W2890891458 hasConcept C2778183499 @default.
• W2890891458 hasConcept C2779134260 @default.
• W2890891458 hasConcept C2779734285 @default.
• W2890891458 hasConcept C2781172350 @default.
• W2890891458 hasConcept C2781192897 @default.
• W2890891458 hasConcept C71924100 @default.
• W2890891458 hasConcept C89916169 @default.
• W2890891458 hasConceptScore W2890891458C126322002 @default.
• W2890891458 hasConceptScore W2890891458C126838900 @default.
• W2890891458 hasConceptScore W2890891458C142724271 @default.

• next