Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890900270> ?p ?o ?g. }
- W2890900270 endingPage "5068" @default.
- W2890900270 startingPage "5062" @default.
- W2890900270 abstract "A previously disclosed protein kinase (PK) CK2-selective inhibitor 4-(2-amino-1,3-thiazol-5-yl)benzoic acid (ATB) and its selenium-containing counterpart (ASB) revealed remarkable room temperature phosphorescence when bound to the ATP pocket of the protein kinase CK2. Conjugation of these fragments with a mimic of CK2 substrate peptide resulted in bisubstrate inhibitors with increased affinity towards the kinase. Attachment of the fluorescent acceptor dye 5-TAMRA to the conjugates led to significant enhancement of intensity of long-lifetime (microsecond-scale) photoluminescence of both sulfur- and selenium-containing compounds. The developed photoluminescent probes make possible selective determination of the concentration of CK2 in cell lysates and characterization of CK2 inhibitors by means of time-gated measurement of photoluminescence." @default.
- W2890900270 created "2018-09-27" @default.
- W2890900270 creator A5003674493 @default.
- W2890900270 creator A5014750512 @default.
- W2890900270 creator A5034006363 @default.
- W2890900270 creator A5042103837 @default.
- W2890900270 creator A5042283392 @default.
- W2890900270 date "2018-10-01" @default.
- W2890900270 modified "2023-10-12" @default.
- W2890900270 title "Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2" @default.
- W2890900270 cites W1556616823 @default.
- W2890900270 cites W1975064033 @default.
- W2890900270 cites W1989018120 @default.
- W2890900270 cites W1989174349 @default.
- W2890900270 cites W1997499490 @default.
- W2890900270 cites W2000980926 @default.
- W2890900270 cites W2004688558 @default.
- W2890900270 cites W2022398543 @default.
- W2890900270 cites W2023328772 @default.
- W2890900270 cites W2031728328 @default.
- W2890900270 cites W2033433713 @default.
- W2890900270 cites W2040810629 @default.
- W2890900270 cites W2058876599 @default.
- W2890900270 cites W2062157293 @default.
- W2890900270 cites W2077331683 @default.
- W2890900270 cites W2080319328 @default.
- W2890900270 cites W2085173493 @default.
- W2890900270 cites W2088938650 @default.
- W2890900270 cites W2093611899 @default.
- W2890900270 cites W2123480261 @default.
- W2890900270 cites W2129381779 @default.
- W2890900270 cites W2151575257 @default.
- W2890900270 cites W2160806585 @default.
- W2890900270 cites W2168759561 @default.
- W2890900270 cites W2170678561 @default.
- W2890900270 cites W2172988438 @default.
- W2890900270 cites W2201698607 @default.
- W2890900270 cites W2251204990 @default.
- W2890900270 cites W2273462154 @default.
- W2890900270 cites W2323096274 @default.
- W2890900270 cites W2332332954 @default.
- W2890900270 cites W2341165250 @default.
- W2890900270 cites W2412544783 @default.
- W2890900270 cites W2563932177 @default.
- W2890900270 cites W2565855260 @default.
- W2890900270 cites W2569328688 @default.
- W2890900270 cites W2581414232 @default.
- W2890900270 cites W2590525769 @default.
- W2890900270 cites W2591001571 @default.
- W2890900270 cites W2594505102 @default.
- W2890900270 cites W2746954662 @default.
- W2890900270 cites W2767869762 @default.
- W2890900270 cites W2806217702 @default.
- W2890900270 cites W2917868259 @default.
- W2890900270 cites W2997481363 @default.
- W2890900270 cites W4252755449 @default.
- W2890900270 doi "https://doi.org/10.1016/j.bmc.2018.09.003" @default.
- W2890900270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30217463" @default.
- W2890900270 hasPublicationYear "2018" @default.
- W2890900270 type Work @default.
- W2890900270 sameAs 2890900270 @default.
- W2890900270 citedByCount "14" @default.
- W2890900270 countsByYear W28909002702019 @default.
- W2890900270 countsByYear W28909002702020 @default.
- W2890900270 countsByYear W28909002702021 @default.
- W2890900270 countsByYear W28909002702022 @default.
- W2890900270 countsByYear W28909002702023 @default.
- W2890900270 crossrefType "journal-article" @default.
- W2890900270 hasAuthorship W2890900270A5003674493 @default.
- W2890900270 hasAuthorship W2890900270A5014750512 @default.
- W2890900270 hasAuthorship W2890900270A5034006363 @default.
- W2890900270 hasAuthorship W2890900270A5042103837 @default.
- W2890900270 hasAuthorship W2890900270A5042283392 @default.
- W2890900270 hasConcept C111368507 @default.
- W2890900270 hasConcept C120665830 @default.
- W2890900270 hasConcept C121332964 @default.
- W2890900270 hasConcept C12554922 @default.
- W2890900270 hasConcept C127313418 @default.
- W2890900270 hasConcept C1276947 @default.
- W2890900270 hasConcept C184235292 @default.
- W2890900270 hasConcept C185592680 @default.
- W2890900270 hasConcept C2777289219 @default.
- W2890900270 hasConcept C2779281246 @default.
- W2890900270 hasConcept C34742353 @default.
- W2890900270 hasConcept C55493867 @default.
- W2890900270 hasConcept C62520636 @default.
- W2890900270 hasConcept C85080765 @default.
- W2890900270 hasConcept C86803240 @default.
- W2890900270 hasConcept C91881484 @default.
- W2890900270 hasConcept C97029542 @default.
- W2890900270 hasConceptScore W2890900270C111368507 @default.
- W2890900270 hasConceptScore W2890900270C120665830 @default.
- W2890900270 hasConceptScore W2890900270C121332964 @default.
- W2890900270 hasConceptScore W2890900270C12554922 @default.
- W2890900270 hasConceptScore W2890900270C127313418 @default.
- W2890900270 hasConceptScore W2890900270C1276947 @default.
- W2890900270 hasConceptScore W2890900270C184235292 @default.
- W2890900270 hasConceptScore W2890900270C185592680 @default.