FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890903170> ?p ?o ?g. }

• W2890903170 endingPage "1273" @default.
• W2890903170 startingPage "1263" @default.
• W2890903170 abstract "Homosalate is an organic ultraviolet filter used in most sunscreens but has been reported to be toxic to marine organisms. The estrogenic activity of homosalate has also been reported, but its endocrine-disrupting effect remains unclear. Although homosalate has been detected in human placental tissues, its effect on the survival of human trophoblast cells needs to be investigated. Therefore, in this study, we evaluated if HTR8/SVneo, a human trophoblast cell line, treated with homosalate showed decreasing proliferative activity in a dose-dependent manner. Homosalate promoted the death of HTR8/SVneo cells with elevated lipid peroxidation and intracellular Ca2+ concentration. It also induced endoplasmic reticulum stress and mitochondrial morphological disturbances associated with the differentiation of human trophoblast cells. However, when the intracellular Ca2+ or reactive oxygen species were removed using BAPTA-AM or N-acetyl-L-cysteine (NAC), the cell proliferation suppressed by homosalate was restored. Homosalate also significantly inhibited the invasion of HTR8/SVneo cells. Furthermore, it modulated phosphoinositide 3-kinase (PI3K)/AKT and mitogen-activated protein kinase (MAPK) signaling pathways, which were involved in the cross-talk between both signaling pathways in HTR8/SVneo cells. Thus, homosalate adversely affects the survival, proliferation, and invasiveness of human trophoblast cells and therefore pregnant women should practice caution while using personal care products containing homosalate." @default.
• W2890903170 created "2018-09-27" @default.
• W2890903170 creator A5007201165 @default.
• W2890903170 creator A5021286537 @default.
• W2890903170 creator A5023474900 @default.
• W2890903170 creator A5046819938 @default.
• W2890903170 date "2018-12-01" @default.
• W2890903170 modified "2023-10-14" @default.
• W2890903170 title "Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways" @default.
• W2890903170 cites W1607588473 @default.
• W2890903170 cites W1969747014 @default.
• W2890903170 cites W1976161806 @default.
• W2890903170 cites W1980232578 @default.
• W2890903170 cites W1981053362 @default.
• W2890903170 cites W1982762531 @default.
• W2890903170 cites W1997664378 @default.
• W2890903170 cites W2005453247 @default.
• W2890903170 cites W2018380507 @default.
• W2890903170 cites W2039848901 @default.
• W2890903170 cites W2044692553 @default.
• W2890903170 cites W2049985139 @default.
• W2890903170 cites W2062221973 @default.
• W2890903170 cites W2084249119 @default.
• W2890903170 cites W2085358480 @default.
• W2890903170 cites W2090537232 @default.
• W2890903170 cites W2093095222 @default.
• W2890903170 cites W2113134733 @default.
• W2890903170 cites W2122910688 @default.
• W2890903170 cites W2138624225 @default.
• W2890903170 cites W2148171335 @default.
• W2890903170 cites W2149675139 @default.
• W2890903170 cites W2160870473 @default.
• W2890903170 cites W2181768659 @default.
• W2890903170 cites W2254382629 @default.
• W2890903170 cites W2259394681 @default.
• W2890903170 cites W2357135671 @default.
• W2890903170 cites W2395853249 @default.
• W2890903170 cites W2520852005 @default.
• W2890903170 cites W2605055711 @default.
• W2890903170 cites W2738392098 @default.
• W2890903170 cites W2760335987 @default.
• W2890903170 cites W2775046625 @default.
• W2890903170 doi "https://doi.org/10.1016/j.envpol.2018.09.092" @default.
• W2890903170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267922" @default.
• W2890903170 hasPublicationYear "2018" @default.
• W2890903170 type Work @default.
• W2890903170 sameAs 2890903170 @default.
• W2890903170 citedByCount "16" @default.
• W2890903170 countsByYear W28909031702019 @default.
• W2890903170 countsByYear W28909031702020 @default.
• W2890903170 countsByYear W28909031702021 @default.
• W2890903170 countsByYear W28909031702022 @default.
• W2890903170 countsByYear W28909031702023 @default.
• W2890903170 crossrefType "journal-article" @default.
• W2890903170 hasAuthorship W2890903170A5007201165 @default.
• W2890903170 hasAuthorship W2890903170A5021286537 @default.
• W2890903170 hasAuthorship W2890903170A5023474900 @default.
• W2890903170 hasAuthorship W2890903170A5046819938 @default.
• W2890903170 hasConcept C172680121 @default.
• W2890903170 hasConcept C184235292 @default.
• W2890903170 hasConcept C2776953305 @default.
• W2890903170 hasConcept C2777495146 @default.
• W2890903170 hasConcept C2779234561 @default.
• W2890903170 hasConcept C54355233 @default.
• W2890903170 hasConcept C55493867 @default.
• W2890903170 hasConcept C57074206 @default.
• W2890903170 hasConcept C62112901 @default.
• W2890903170 hasConcept C62478195 @default.
• W2890903170 hasConcept C75217442 @default.
• W2890903170 hasConcept C79879829 @default.
• W2890903170 hasConcept C86554907 @default.
• W2890903170 hasConcept C86803240 @default.
• W2890903170 hasConcept C95444343 @default.
• W2890903170 hasConcept C97029542 @default.
• W2890903170 hasConceptScore W2890903170C172680121 @default.
• W2890903170 hasConceptScore W2890903170C184235292 @default.
• W2890903170 hasConceptScore W2890903170C2776953305 @default.
• W2890903170 hasConceptScore W2890903170C2777495146 @default.
• W2890903170 hasConceptScore W2890903170C2779234561 @default.
• W2890903170 hasConceptScore W2890903170C54355233 @default.
• W2890903170 hasConceptScore W2890903170C55493867 @default.
• W2890903170 hasConceptScore W2890903170C57074206 @default.
• W2890903170 hasConceptScore W2890903170C62112901 @default.
• W2890903170 hasConceptScore W2890903170C62478195 @default.
• W2890903170 hasConceptScore W2890903170C75217442 @default.
• W2890903170 hasConceptScore W2890903170C79879829 @default.
• W2890903170 hasConceptScore W2890903170C86554907 @default.
• W2890903170 hasConceptScore W2890903170C86803240 @default.
• W2890903170 hasConceptScore W2890903170C95444343 @default.
• W2890903170 hasConceptScore W2890903170C97029542 @default.
• W2890903170 hasFunder F4320322034 @default.
• W2890903170 hasFunder F4320322107 @default.
• W2890903170 hasLocation W28909031701 @default.
• W2890903170 hasLocation W28909031702 @default.
• W2890903170 hasOpenAccess W2890903170 @default.
• W2890903170 hasPrimaryLocation W28909031701 @default.
• W2890903170 hasRelatedWork W1986526737 @default.
• W2890903170 hasRelatedWork W2038169799 @default.

• next