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- W2890905404 abstract "In the majority of phase III clinical trials, patients are generally excluded on the basis of specific comorbidities, performance status Eastern Cooperative Oncology Group ≥ 2, age ≥ 65 years, previous malignancies, brain metastases, active infections, psychiatric disorders, non-measurable disease, number and type of previous lines of chemotherapies or biologic therapies. A question is raised: Can results of phase IIIstudies be extended to the general population? There is increasing attention to and a resurgence of some terms as real world or real practice which are wrongly viewed as contrary to clinical trial protocols. In fact, the general perception is that a contraposition exists between wrong (retrospective and biased) and right (prospective, randomized, well statistically designed) clinical research. We have to change this perspective. Real practice studies, generally retrospective in their nature, deserve to be reevaluated; biases are physiologically present but their punctual and rigorous description and analysis can help the interpretation of and in some cases reinforce results and their hypothesis-generating power. The correct and balanced interaction between clinical trials and real practice reports can help the scientific community to improve the knowledge on anti-cancer drug efficacy." @default.
- W2890905404 created "2018-09-27" @default.
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- W2890905404 date "2018-09-15" @default.
- W2890905404 modified "2023-09-23" @default.
- W2890905404 title "Real practice studies in oncology: A positive perspective" @default.
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- W2890905404 doi "https://doi.org/10.4251/wjgo.v10.i9.228" @default.
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