Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890908546> ?p ?o ?g. }
- W2890908546 endingPage "139" @default.
- W2890908546 startingPage "131" @default.
- W2890908546 abstract "Propagation of genetic material is central to the survival and fitness of multicellular organisms. To efficiently duplicate eukaryotic genomes of sizes between ~107 bp (yeast) to ~1011 bp (plants), replication initiates from multiple start sites called “replication origins” distributed on multiple chromosomes [1]. This strategy imposes a need for cellular controls to ensure complete DNA replication while also preventing re-replication, which can cause genomic instability, leading to developmental diseases (e.g. Meier-Gorlin Syndrome) and cancer [2,3]. Once-per-cell-cycle replication requires the oscillation of cyclin-dependent-kinases (CDKs) and ubiquitin-mediated proteolysis activities [4], establishing two discrete time periods during which origin licensing (assembly of replicative helicases onto origins) and origin firing (activation of helicases) occur in a mutually exclusive manner. Recent progress in acquiring structural information on origin licensing has advanced our mechanistic understanding and regulation of this process. This review discusses current knowledge of origin licensing and compares the origin recognition machinery with other multi-subunit, ATP-driven cellular motors that are required for later stages of DNA replication." @default.
- W2890908546 created "2018-09-27" @default.
- W2890908546 creator A5007546810 @default.
- W2890908546 creator A5056764359 @default.
- W2890908546 creator A5071437258 @default.
- W2890908546 creator A5076746607 @default.
- W2890908546 date "2018-12-01" @default.
- W2890908546 modified "2023-09-27" @default.
- W2890908546 title "A structural view of the initiators for chromosome replication" @default.
- W2890908546 cites W104862819 @default.
- W2890908546 cites W1136494239 @default.
- W2890908546 cites W1771989280 @default.
- W2890908546 cites W1941109656 @default.
- W2890908546 cites W1968946850 @default.
- W2890908546 cites W1975935807 @default.
- W2890908546 cites W1977131457 @default.
- W2890908546 cites W1995958788 @default.
- W2890908546 cites W1999751951 @default.
- W2890908546 cites W2001222878 @default.
- W2890908546 cites W2006695093 @default.
- W2890908546 cites W2007214324 @default.
- W2890908546 cites W2007433956 @default.
- W2890908546 cites W2014717496 @default.
- W2890908546 cites W2027271664 @default.
- W2890908546 cites W2031167624 @default.
- W2890908546 cites W2033139694 @default.
- W2890908546 cites W2033349546 @default.
- W2890908546 cites W2034458429 @default.
- W2890908546 cites W2035507249 @default.
- W2890908546 cites W2038174431 @default.
- W2890908546 cites W2043249713 @default.
- W2890908546 cites W2045178475 @default.
- W2890908546 cites W2049171516 @default.
- W2890908546 cites W2049231478 @default.
- W2890908546 cites W2052079265 @default.
- W2890908546 cites W2058104615 @default.
- W2890908546 cites W2059208699 @default.
- W2890908546 cites W2059531322 @default.
- W2890908546 cites W2059594509 @default.
- W2890908546 cites W2061449183 @default.
- W2890908546 cites W2063045156 @default.
- W2890908546 cites W2063865760 @default.
- W2890908546 cites W2071019833 @default.
- W2890908546 cites W2077496082 @default.
- W2890908546 cites W2080183231 @default.
- W2890908546 cites W2082924345 @default.
- W2890908546 cites W2087660608 @default.
- W2890908546 cites W2093481013 @default.
- W2890908546 cites W2099117602 @default.
- W2890908546 cites W2099487576 @default.
- W2890908546 cites W2102847068 @default.
- W2890908546 cites W2104190830 @default.
- W2890908546 cites W2117649003 @default.
- W2890908546 cites W2121431496 @default.
- W2890908546 cites W2122554623 @default.
- W2890908546 cites W2127043939 @default.
- W2890908546 cites W2130791173 @default.
- W2890908546 cites W2134367258 @default.
- W2890908546 cites W2135968198 @default.
- W2890908546 cites W2138404467 @default.
- W2890908546 cites W2149359491 @default.
- W2890908546 cites W2151836800 @default.
- W2890908546 cites W2154467428 @default.
- W2890908546 cites W2165710627 @default.
- W2890908546 cites W2166903547 @default.
- W2890908546 cites W2172114459 @default.
- W2890908546 cites W2197308808 @default.
- W2890908546 cites W2279836301 @default.
- W2890908546 cites W2283974241 @default.
- W2890908546 cites W2559896842 @default.
- W2890908546 cites W2577454101 @default.
- W2890908546 cites W2581672249 @default.
- W2890908546 cites W2586965518 @default.
- W2890908546 cites W2588958371 @default.
- W2890908546 cites W2625839772 @default.
- W2890908546 cites W2737463560 @default.
- W2890908546 cites W2738093081 @default.
- W2890908546 cites W2766127952 @default.
- W2890908546 cites W2792930515 @default.
- W2890908546 cites W2808295680 @default.
- W2890908546 cites W2810211328 @default.
- W2890908546 doi "https://doi.org/10.1016/j.sbi.2018.08.003" @default.
- W2890908546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6295364" @default.
- W2890908546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30218786" @default.
- W2890908546 hasPublicationYear "2018" @default.
- W2890908546 type Work @default.
- W2890908546 sameAs 2890908546 @default.
- W2890908546 citedByCount "12" @default.
- W2890908546 countsByYear W28909085462019 @default.
- W2890908546 countsByYear W28909085462020 @default.
- W2890908546 countsByYear W28909085462021 @default.
- W2890908546 countsByYear W28909085462022 @default.
- W2890908546 crossrefType "journal-article" @default.
- W2890908546 hasAuthorship W2890908546A5007546810 @default.
- W2890908546 hasAuthorship W2890908546A5056764359 @default.
- W2890908546 hasAuthorship W2890908546A5071437258 @default.
- W2890908546 hasAuthorship W2890908546A5076746607 @default.
- W2890908546 hasBestOaLocation W28909085462 @default.