FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890909324> ?p ?o ?g. }

• W2890909324 endingPage "105" @default.
• W2890909324 startingPage "96" @default.
• W2890909324 abstract "Organophosphorus nerve agents still represent a serious risk to human health. In the French armed forces, the current emergency treatment against OP intoxications is a fully licensed wet-dry dual-chambered autoinjector (Ineurope ®), that contains pralidoxime methylsulfate (2-PAM) to reactivate inhibited acetylcholinesterase (AChE), atropine sulfate (AS) and avizafone chlorhydrate (AVZ). While this treatment is effective against several of the known nerve agents, it shows little efficacy against the Russian VX (VR), one of the most toxic compounds. HI-6 dimethanesulfonate (HI-6 DMS) is an oxime able to reactivate in vitro and in vivo VR-inhibited AChE. To confirm the superiority of HI-6 DMS towards 2-PAM prior to licensing, we compared the two 3-drug-combinations (HI-6 vs 2-PAM, 33 and 18 mg/kg respectively, equimolar doses; AS/AVZ 0.25/0.175 mg/kg respectively) in VR-poisoned cynomolgus macaques, the model required by the French drug regulatory agency. In parallel we performed HI-6 pharmacokinetics analysis using a one compartment model. A better efficacy of the HI-6 DMS combination was clearly observed: up to 5 LD50 of VR (i.m.), a single administration of the HI-6 DMS combination, shortly after the onset of clinical signs, prevented death of the four intoxicated animals. Conversely 2-PAM only prevented death in one out of three subjects exposed to the same amount of VR. As expected with V agents, reinhibition of blood AChE was observed but without any apparent impact on the clinical recovery of the animals. A single administration of the HI-6 DMS combination was still but partially effective at 15 LD50 of VR, allowing a 50% survival rate." @default.
• W2890909324 created "2018-09-27" @default.
• W2890909324 creator A5002627230 @default.
• W2890909324 creator A5005081715 @default.
• W2890909324 creator A5031913311 @default.
• W2890909324 creator A5033402628 @default.
• W2890909324 creator A5036167770 @default.
• W2890909324 creator A5048172282 @default.
• W2890909324 creator A5064700039 @default.
• W2890909324 creator A5069487066 @default.
• W2890909324 creator A5081753623 @default.
• W2890909324 date "2018-12-01" @default.
• W2890909324 modified "2023-10-18" @default.
• W2890909324 title "Superior efficacy of HI-6 dimethanesulfonate over pralidoxime methylsulfate against Russian VX poisoning in cynomolgus monkeys (Macaca fascicularis)" @default.
• W2890909324 cites W1648076111 @default.
• W2890909324 cites W1967351568 @default.
• W2890909324 cites W1971424254 @default.
• W2890909324 cites W1971857258 @default.
• W2890909324 cites W1972590941 @default.
• W2890909324 cites W1979826701 @default.
• W2890909324 cites W1980861100 @default.
• W2890909324 cites W1981147274 @default.
• W2890909324 cites W1984790689 @default.
• W2890909324 cites W1996431255 @default.
• W2890909324 cites W1998295249 @default.
• W2890909324 cites W2006312252 @default.
• W2890909324 cites W2010238384 @default.
• W2890909324 cites W2014652437 @default.
• W2890909324 cites W2018338529 @default.
• W2890909324 cites W2019539155 @default.
• W2890909324 cites W2021698574 @default.
• W2890909324 cites W2024662280 @default.
• W2890909324 cites W2025139145 @default.
• W2890909324 cites W2025886956 @default.
• W2890909324 cites W2026027973 @default.
• W2890909324 cites W2030203690 @default.
• W2890909324 cites W2034232580 @default.
• W2890909324 cites W2034618227 @default.
• W2890909324 cites W2040932827 @default.
• W2890909324 cites W2041496054 @default.
• W2890909324 cites W2046294255 @default.
• W2890909324 cites W2047060919 @default.
• W2890909324 cites W2048299072 @default.
• W2890909324 cites W2048890215 @default.
• W2890909324 cites W2049588132 @default.
• W2890909324 cites W2059292859 @default.
• W2890909324 cites W2059497480 @default.
• W2890909324 cites W2060975068 @default.
• W2890909324 cites W2063312584 @default.
• W2890909324 cites W2064511062 @default.
• W2890909324 cites W2066256769 @default.
• W2890909324 cites W2067689565 @default.
• W2890909324 cites W2069192830 @default.
• W2890909324 cites W2069832212 @default.
• W2890909324 cites W2074733231 @default.
• W2890909324 cites W2079960443 @default.
• W2890909324 cites W2086563378 @default.
• W2890909324 cites W2105691682 @default.
• W2890909324 cites W2107952228 @default.
• W2890909324 cites W2110740625 @default.
• W2890909324 cites W2112904166 @default.
• W2890909324 cites W2127062451 @default.
• W2890909324 cites W2136899020 @default.
• W2890909324 cites W2152619634 @default.
• W2890909324 cites W2619496385 @default.
• W2890909324 cites W2738014943 @default.
• W2890909324 cites W2784225743 @default.
• W2890909324 cites W4244135429 @default.
• W2890909324 doi "https://doi.org/10.1016/j.tox.2018.09.005" @default.
• W2890909324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30218682" @default.
• W2890909324 hasPublicationYear "2018" @default.
• W2890909324 type Work @default.
• W2890909324 sameAs 2890909324 @default.
• W2890909324 citedByCount "5" @default.
• W2890909324 countsByYear W28909093242020 @default.
• W2890909324 countsByYear W28909093242022 @default.
• W2890909324 countsByYear W28909093242023 @default.
• W2890909324 crossrefType "journal-article" @default.
• W2890909324 hasAuthorship W2890909324A5002627230 @default.
• W2890909324 hasAuthorship W2890909324A5005081715 @default.
• W2890909324 hasAuthorship W2890909324A5031913311 @default.
• W2890909324 hasAuthorship W2890909324A5033402628 @default.
• W2890909324 hasAuthorship W2890909324A5036167770 @default.
• W2890909324 hasAuthorship W2890909324A5048172282 @default.
• W2890909324 hasAuthorship W2890909324A5064700039 @default.
• W2890909324 hasAuthorship W2890909324A5069487066 @default.
• W2890909324 hasAuthorship W2890909324A5081753623 @default.
• W2890909324 hasConcept C112705442 @default.
• W2890909324 hasConcept C150903083 @default.
• W2890909324 hasConcept C178790620 @default.
• W2890909324 hasConcept C181199279 @default.
• W2890909324 hasConcept C185592680 @default.
• W2890909324 hasConcept C207001950 @default.
• W2890909324 hasConcept C2775859210 @default.
• W2890909324 hasConcept C2776327929 @default.
• W2890909324 hasConcept C2778706303 @default.
• W2890909324 hasConcept C2778816929 @default.
• W2890909324 hasConcept C2779059548 @default.

• next