FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890910536> ?p ?o ?g. }

• W2890910536 endingPage "1017" @default.
• W2890910536 startingPage "1017" @default.
• W2890910536 abstract "<h3>Importance</h3> Recanalization of intracranial thrombus is associated with improved clinical outcome in patients with acute ischemic stroke. The association of intravenous alteplase treatment and thrombus characteristics with recanalization over time is important for stroke triage and future trial design. <h3>Objective</h3> To examine recanalization over time across a range of intracranial thrombus occlusion sites and clinical and imaging characteristics in patients with ischemic stroke treated with intravenous alteplase or not treated with alteplase. <h3>Design, Setting, and Participants</h3> Multicenter prospective cohort study of 575 patients from 12 centers (in Canada, Spain, South Korea, the Czech Republic, and Turkey) with acute ischemic stroke and intracranial arterial occlusion demonstrated on computed tomographic angiography (CTA). <h3>Exposures</h3> Demographics, clinical characteristics, time from alteplase to recanalization, and intracranial thrombus characteristics (location and permeability) defined on CTA. <h3>Main Outcomes and Measures</h3> Recanalization on repeat CTA or on first angiographic acquisition of affected intracranial circulation obtained within 6 hours of baseline CTA, defined using the revised arterial occlusion scale (rAOL) (scores from 0 [primary occlusive lesion remains the same] to 3 [complete revascularization of primary occlusion]). <h3>Results</h3> Among 575 patients (median age, 72 years [IQR, 63-80]; 51.5% men; median time from patient last known well to baseline CTA of 114 minutes [IQR, 74-180]), 275 patients (47.8%) received intravenous alteplase only, 195 (33.9%) received intravenous alteplase plus endovascular thrombectomy, 48 (8.3%) received endovascular thrombectomy alone, and 57 (9.9%) received conservative treatment. Median time from baseline CTA to recanalization assessment was 158 minutes (IQR, 79-268); median time from intravenous alteplase start to recanalization assessment was 132.5 minutes (IQR, 62-238). Successful recanalization occurred at an unadjusted rate of 27.3% (157/575) overall, including in 30.4% (143/470) of patients who received intravenous alteplase and 13.3% (14/105) who did not (difference, 17.1% [95% CI, 10.2%-25.8%]). Among patients receiving alteplase, the following factors were associated with recanalization: time from treatment start to recanalization assessment (OR, 1.28 for every 30-minute increase in time [95% CI, 1.18-1.38]), more distal thrombus location, eg, distal M1 middle cerebral artery (39/84 [46.4%]) vs internal carotid artery (10/92 [10.9%]) (OR, 5.61 [95% CI, 2.38-13.26]), and higher residual flow (thrombus permeability) grade, eg, hairline streak (30/45 [66.7%]) vs none (91/377 [24.1%]) (OR, 7.03 [95% CI, 3.32-14.87]). <h3>Conclusions and Relevance</h3> In patients with acute ischemic stroke, more distal thrombus location, greater thrombus permeability, and longer time to recanalization assessment were associated with recanalization of arterial occlusion after administration of intravenous alteplase; among patients who did not receive alteplase, rates of arterial recanalization were low. These findings may help inform treatment and triage decisions in patients with acute ischemic stroke." @default.
• W2890910536 created "2018-09-27" @default.
• W2890910536 creator A5008933798 @default.
• W2890910536 creator A5009156637 @default.
• W2890910536 creator A5012894644 @default.
• W2890910536 creator A5013486460 @default.
• W2890910536 creator A5015783013 @default.
• W2890910536 creator A5018123409 @default.
• W2890910536 creator A5020373936 @default.
• W2890910536 creator A5021195319 @default.
• W2890910536 creator A5044371836 @default.
• W2890910536 creator A5046430859 @default.
• W2890910536 creator A5050159846 @default.
• W2890910536 creator A5055858701 @default.
• W2890910536 creator A5060792245 @default.
• W2890910536 creator A5062309016 @default.
• W2890910536 creator A5064865020 @default.
• W2890910536 creator A5065538461 @default.
• W2890910536 creator A5066076994 @default.
• W2890910536 creator A5066410968 @default.
• W2890910536 creator A5067917496 @default.
• W2890910536 creator A5068657718 @default.
• W2890910536 creator A5070359183 @default.
• W2890910536 creator A5072599699 @default.
• W2890910536 creator A5076246772 @default.
• W2890910536 creator A5080100010 @default.
• W2890910536 creator A5080305729 @default.
• W2890910536 creator A5080971882 @default.
• W2890910536 creator A5084100416 @default.
• W2890910536 creator A5084818758 @default.
• W2890910536 creator A5089131804 @default.
• W2890910536 date "2018-09-11" @default.
• W2890910536 modified "2023-10-16" @default.
• W2890910536 title "Association of Clinical, Imaging, and Thrombus Characteristics With Recanalization of Visible Intracranial Occlusion in Patients With Acute Ischemic Stroke" @default.
• W2890910536 cites W1760136589 @default.
• W2890910536 cites W1935753041 @default.
• W2890910536 cites W1969672216 @default.
• W2890910536 cites W1975688998 @default.
• W2890910536 cites W1996802760 @default.
• W2890910536 cites W2002799366 @default.
• W2890910536 cites W2011766727 @default.
• W2890910536 cites W2024691831 @default.
• W2890910536 cites W2036649471 @default.
• W2890910536 cites W2049925123 @default.
• W2890910536 cites W2070896918 @default.
• W2890910536 cites W2101188164 @default.
• W2890910536 cites W2102447759 @default.
• W2890910536 cites W2107972676 @default.
• W2890910536 cites W2113442572 @default.
• W2890910536 cites W2118738743 @default.
• W2890910536 cites W2121300729 @default.
• W2890910536 cites W2144953162 @default.
• W2890910536 cites W2155683152 @default.
• W2890910536 cites W2156845192 @default.
• W2890910536 cites W2159233098 @default.
• W2890910536 cites W2170297325 @default.
• W2890910536 cites W2171058244 @default.
• W2890910536 cites W2277258071 @default.
• W2890910536 cites W2292308933 @default.
• W2890910536 cites W2308250829 @default.
• W2890910536 cites W2316593535 @default.
• W2890910536 cites W2501634750 @default.
• W2890910536 cites W2526978419 @default.
• W2890910536 cites W2563068144 @default.
• W2890910536 cites W2599815449 @default.
• W2890910536 cites W2733458140 @default.
• W2890910536 cites W2802880180 @default.
• W2890910536 cites W4233611865 @default.
• W2890910536 cites W4240271001 @default.
• W2890910536 doi "https://doi.org/10.1001/jama.2018.12498" @default.
• W2890910536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6143104" @default.
• W2890910536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30208455" @default.
• W2890910536 hasPublicationYear "2018" @default.
• W2890910536 type Work @default.
• W2890910536 sameAs 2890910536 @default.
• W2890910536 citedByCount "169" @default.
• W2890910536 countsByYear W28909105362018 @default.
• W2890910536 countsByYear W28909105362019 @default.
• W2890910536 countsByYear W28909105362020 @default.
• W2890910536 countsByYear W28909105362021 @default.
• W2890910536 countsByYear W28909105362022 @default.
• W2890910536 countsByYear W28909105362023 @default.
• W2890910536 crossrefType "journal-article" @default.
• W2890910536 hasAuthorship W2890910536A5008933798 @default.
• W2890910536 hasAuthorship W2890910536A5009156637 @default.
• W2890910536 hasAuthorship W2890910536A5012894644 @default.
• W2890910536 hasAuthorship W2890910536A5013486460 @default.
• W2890910536 hasAuthorship W2890910536A5015783013 @default.
• W2890910536 hasAuthorship W2890910536A5018123409 @default.
• W2890910536 hasAuthorship W2890910536A5020373936 @default.
• W2890910536 hasAuthorship W2890910536A5021195319 @default.
• W2890910536 hasAuthorship W2890910536A5044371836 @default.
• W2890910536 hasAuthorship W2890910536A5046430859 @default.
• W2890910536 hasAuthorship W2890910536A5050159846 @default.
• W2890910536 hasAuthorship W2890910536A5055858701 @default.
• W2890910536 hasAuthorship W2890910536A5060792245 @default.
• W2890910536 hasAuthorship W2890910536A5062309016 @default.
• W2890910536 hasAuthorship W2890910536A5064865020 @default.

• next