FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890911396> ?p ?o ?g. }

• W2890911396 endingPage "13" @default.
• W2890911396 startingPage "1" @default.
• W2890911396 abstract "The key transcription factors of T helper cell subpopulations, including T-bet, GATA3, ROR γ t, and Foxp3 are involved in various autoimmune diseases. Whether methylation of these master transcription factors is associated with the development of experimental autoimmune uveitis (EAU) and the possible epigenetic regulatory mechanisms involved has however not yet been addressed. In our study, significant methylation changes in both Tbx21 and Rorc were observed in one CpG site in the retinas of EAU mice. Two CpG sites of Tbx21 and one CpG site of Rorc showed significant dynamic methylation changes in the RPE-choroid complex during EAU. The mRNA expressions of Tbx21 and Rorc in both the retinas and RPE-choroid complexes correlated with the methylation changes at the various time points during EAU development. The methylation changes were associated with the production of the Th1/Th17 cells’ signature cytokines, IFN- γ and IL-17. Dynamic changes in mRNA expression of DNA methyltransferases (DNMT1) were also noted, which may be related to the observed methylation changes of these genes. The present study provides evidence that DNA methylation of Tbx21 and Rorc may be associated with the development of EAU. DNMT1 activation may have an important effect on regulating DNA methylation dynamics." @default.
• W2890911396 created "2018-09-27" @default.
• W2890911396 creator A5004045598 @default.
• W2890911396 creator A5005016013 @default.
• W2890911396 creator A5059340675 @default.
• W2890911396 creator A5067126588 @default.
• W2890911396 creator A5084574862 @default.
• W2890911396 creator A5084618889 @default.
• W2890911396 date "2018-09-04" @default.
• W2890911396 modified "2023-09-28" @default.
• W2890911396 title "Dynamic DNA Methylation Changes of <i>Tbx21</i> and <i>Rorc</i> during Experimental Autoimmune Uveitis in Mice" @default.
• W2890911396 cites W1484073183 @default.
• W2890911396 cites W148867506 @default.
• W2890911396 cites W1497312799 @default.
• W2890911396 cites W1525096334 @default.
• W2890911396 cites W1970464961 @default.
• W2890911396 cites W1988290255 @default.
• W2890911396 cites W1999240025 @default.
• W2890911396 cites W2007146260 @default.
• W2890911396 cites W2011435677 @default.
• W2890911396 cites W2019536120 @default.
• W2890911396 cites W2019615790 @default.
• W2890911396 cites W2026053005 @default.
• W2890911396 cites W2037269612 @default.
• W2890911396 cites W2049275241 @default.
• W2890911396 cites W2057030367 @default.
• W2890911396 cites W2067036337 @default.
• W2890911396 cites W2074428530 @default.
• W2890911396 cites W2074918990 @default.
• W2890911396 cites W2084970621 @default.
• W2890911396 cites W2087472552 @default.
• W2890911396 cites W2103283658 @default.
• W2890911396 cites W2106655704 @default.
• W2890911396 cites W2106931669 @default.
• W2890911396 cites W2117247812 @default.
• W2890911396 cites W2121451687 @default.
• W2890911396 cites W2122586908 @default.
• W2890911396 cites W2123032740 @default.
• W2890911396 cites W2135593075 @default.
• W2890911396 cites W2138699372 @default.
• W2890911396 cites W2138710156 @default.
• W2890911396 cites W2145138299 @default.
• W2890911396 cites W2150117087 @default.
• W2890911396 cites W2157232603 @default.
• W2890911396 cites W2161224111 @default.
• W2890911396 cites W2318164054 @default.
• W2890911396 cites W2338110118 @default.
• W2890911396 cites W2516694377 @default.
• W2890911396 cites W2593616538 @default.
• W2890911396 cites W2603914546 @default.
• W2890911396 cites W2606040064 @default.
• W2890911396 cites W2607485250 @default.
• W2890911396 cites W386629458 @default.
• W2890911396 cites W54573954 @default.
• W2890911396 cites W597953878 @default.
• W2890911396 doi "https://doi.org/10.1155/2018/9129163" @default.
• W2890911396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6142759" @default.
• W2890911396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254507" @default.
• W2890911396 hasPublicationYear "2018" @default.
• W2890911396 type Work @default.
• W2890911396 sameAs 2890911396 @default.
• W2890911396 citedByCount "13" @default.
• W2890911396 countsByYear W28909113962020 @default.
• W2890911396 countsByYear W28909113962021 @default.
• W2890911396 countsByYear W28909113962022 @default.
• W2890911396 countsByYear W28909113962023 @default.
• W2890911396 crossrefType "journal-article" @default.
• W2890911396 hasAuthorship W2890911396A5004045598 @default.
• W2890911396 hasAuthorship W2890911396A5005016013 @default.
• W2890911396 hasAuthorship W2890911396A5059340675 @default.
• W2890911396 hasAuthorship W2890911396A5067126588 @default.
• W2890911396 hasAuthorship W2890911396A5084574862 @default.
• W2890911396 hasAuthorship W2890911396A5084618889 @default.
• W2890911396 hasBestOaLocation W28909113961 @default.
• W2890911396 hasConcept C104317684 @default.
• W2890911396 hasConcept C140173407 @default.
• W2890911396 hasConcept C150194340 @default.
• W2890911396 hasConcept C175211621 @default.
• W2890911396 hasConcept C190727270 @default.
• W2890911396 hasConcept C203014093 @default.
• W2890911396 hasConcept C2779727006 @default.
• W2890911396 hasConcept C33288867 @default.
• W2890911396 hasConcept C41091548 @default.
• W2890911396 hasConcept C54355233 @default.
• W2890911396 hasConcept C74737994 @default.
• W2890911396 hasConcept C86339819 @default.
• W2890911396 hasConcept C86803240 @default.
• W2890911396 hasConcept C8891405 @default.
• W2890911396 hasConcept C91965660 @default.
• W2890911396 hasConceptScore W2890911396C104317684 @default.
• W2890911396 hasConceptScore W2890911396C140173407 @default.
• W2890911396 hasConceptScore W2890911396C150194340 @default.
• W2890911396 hasConceptScore W2890911396C175211621 @default.
• W2890911396 hasConceptScore W2890911396C190727270 @default.
• W2890911396 hasConceptScore W2890911396C203014093 @default.
• W2890911396 hasConceptScore W2890911396C2779727006 @default.
• W2890911396 hasConceptScore W2890911396C33288867 @default.
• W2890911396 hasConceptScore W2890911396C41091548 @default.

• next