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- W2890911761 abstract "Significance Tissue plasminogen activator (tPA) is employed in stroke patients to lyse blood clots, but its therapeutic potential in brain trauma victims is far from settled, partly due to fears of internal bleeding. The long-term effects of tPA upon the white matter of the brain and neurological outcomes after head trauma are also uncertain. To address these gaps, we performed electrophysiological, anatomical, and behavioral studies in genetically modified or wild-type mice subjected to traumatic brain injury and infused tPA through the nose. We found that natural or synthetic forms of tPA protect or repair white matter tracts without magnifying internal bleeding. Thus, tPA treatment after brain injury promotes communication across neuronal networks through nerve fiber tracts and improves long-term adaptive behavior." @default.
- W2890911761 created "2018-09-27" @default.
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- W2890911761 date "2018-09-10" @default.
- W2890911761 modified "2023-09-26" @default.
- W2890911761 title "Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury" @default.
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- W2890911761 doi "https://doi.org/10.1073/pnas.1810693115" @default.
- W2890911761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6166834" @default.
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