FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890912772> ?p ?o ?g. }

• W2890912772 endingPage "184" @default.
• W2890912772 startingPage "161" @default.
• W2890912772 abstract "Our goal was to develop an initial study for the proof of concept whereby gastric cancer organoids are used as an approach to predict the tumor response in individual patients.Organoids were derived from resected gastric cancer tumors (huTGOs) or normal stomach tissue collected from sleeve gastrectomies (huFGOs). Organoid cultures were treated with standard-of-care chemotherapeutic drugs corresponding to patient treatment: epirubicin, oxaliplatin, and 5-fluorouracil. Organoid response to chemotherapeutic treatment was correlated with the tumor response in each patient from whom the huTGOs were derived. HuTGOs were orthotopically transplanted into the gastric mucosa of NOD scid gamma mice.Whereas huFGOs exhibited a half maximal inhibitory concentration that was similar among organoid lines, divergent responses and varying half maximal inhibitory concentration values among the huTGO lines were observed in response to chemotherapeutic drugs. HuTGOs that were sensitive to treatment were derived from a patient with a near complete tumor response to chemotherapy. However, organoids resistant to treatment were derived from patients who exhibited no response to chemotherapy. Orthotropic transplantation of organoids resulted in the engraftment and development of human adenocarcinoma. RNA sequencing revealed that huTGOs closely resembled the patient's native tumor tissue and not commonly used gastric cancer cell lines and cell lines derived from the organoid cultures.The treatment of patient-derived organoids alongside patients from whom cultures were derived will ultimately test their usefulness to predict individual therapy response and patient outcome." @default.
• W2890912772 created "2018-09-27" @default.
• W2890912772 creator A5006772845 @default.
• W2890912772 creator A5015642211 @default.
• W2890912772 creator A5019403449 @default.
• W2890912772 creator A5021452379 @default.
• W2890912772 creator A5029205459 @default.
• W2890912772 creator A5032751641 @default.
• W2890912772 creator A5047448446 @default.
• W2890912772 creator A5053422720 @default.
• W2890912772 creator A5055095007 @default.
• W2890912772 creator A5057856712 @default.
• W2890912772 creator A5061904440 @default.
• W2890912772 creator A5069272714 @default.
• W2890912772 creator A5071949521 @default.
• W2890912772 creator A5078818594 @default.
• W2890912772 creator A5085693318 @default.
• W2890912772 date "2019-01-01" @default.
• W2890912772 modified "2023-10-15" @default.
• W2890912772 title "An Organoid-Based Preclinical Model of Human Gastric Cancer" @default.
• W2890912772 cites W1128365645 @default.
• W2890912772 cites W1973094248 @default.
• W2890912772 cites W1976269164 @default.
• W2890912772 cites W1983830732 @default.
• W2890912772 cites W1989593129 @default.
• W2890912772 cites W1997338647 @default.
• W2890912772 cites W2000369564 @default.
• W2890912772 cites W2003911004 @default.
• W2890912772 cites W2005829575 @default.
• W2890912772 cites W2016789384 @default.
• W2890912772 cites W2018044006 @default.
• W2890912772 cites W2033917892 @default.
• W2890912772 cites W2055668535 @default.
• W2890912772 cites W2057789711 @default.
• W2890912772 cites W2067746951 @default.
• W2890912772 cites W2075657881 @default.
• W2890912772 cites W2085844606 @default.
• W2890912772 cites W2087666721 @default.
• W2890912772 cites W2107277218 @default.
• W2890912772 cites W2114104545 @default.
• W2890912772 cites W2120295238 @default.
• W2890912772 cites W2122781730 @default.
• W2890912772 cites W2126532720 @default.
• W2890912772 cites W2134891969 @default.
• W2890912772 cites W2141393790 @default.
• W2890912772 cites W2144776283 @default.
• W2890912772 cites W2152239989 @default.
• W2890912772 cites W2152811375 @default.
• W2890912772 cites W2192080449 @default.
• W2890912772 cites W2293828571 @default.
• W2890912772 cites W2399328912 @default.
• W2890912772 cites W2499809487 @default.
• W2890912772 cites W2513912683 @default.
• W2890912772 cites W2517324541 @default.
• W2890912772 cites W2617890432 @default.
• W2890912772 cites W2783528081 @default.
• W2890912772 cites W2799791049 @default.
• W2890912772 doi "https://doi.org/10.1016/j.jcmgh.2018.09.008" @default.
• W2890912772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279812" @default.
• W2890912772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30522949" @default.
• W2890912772 hasPublicationYear "2019" @default.
• W2890912772 type Work @default.
• W2890912772 sameAs 2890912772 @default.
• W2890912772 citedByCount "88" @default.
• W2890912772 countsByYear W28909127722019 @default.
• W2890912772 countsByYear W28909127722020 @default.
• W2890912772 countsByYear W28909127722021 @default.
• W2890912772 countsByYear W28909127722022 @default.
• W2890912772 countsByYear W28909127722023 @default.
• W2890912772 crossrefType "journal-article" @default.
• W2890912772 hasAuthorship W2890912772A5006772845 @default.
• W2890912772 hasAuthorship W2890912772A5015642211 @default.
• W2890912772 hasAuthorship W2890912772A5019403449 @default.
• W2890912772 hasAuthorship W2890912772A5021452379 @default.
• W2890912772 hasAuthorship W2890912772A5029205459 @default.
• W2890912772 hasAuthorship W2890912772A5032751641 @default.
• W2890912772 hasAuthorship W2890912772A5047448446 @default.
• W2890912772 hasAuthorship W2890912772A5053422720 @default.
• W2890912772 hasAuthorship W2890912772A5055095007 @default.
• W2890912772 hasAuthorship W2890912772A5057856712 @default.
• W2890912772 hasAuthorship W2890912772A5061904440 @default.
• W2890912772 hasAuthorship W2890912772A5069272714 @default.
• W2890912772 hasAuthorship W2890912772A5071949521 @default.
• W2890912772 hasAuthorship W2890912772A5078818594 @default.
• W2890912772 hasAuthorship W2890912772A5085693318 @default.
• W2890912772 hasBestOaLocation W28909127721 @default.
• W2890912772 hasConcept C121608353 @default.
• W2890912772 hasConcept C126322002 @default.
• W2890912772 hasConcept C142724271 @default.
• W2890912772 hasConcept C143998085 @default.
• W2890912772 hasConcept C2776694085 @default.
• W2890912772 hasConcept C2780962732 @default.
• W2890912772 hasConcept C2911091166 @default.
• W2890912772 hasConcept C31695470 @default.
• W2890912772 hasConcept C502942594 @default.
• W2890912772 hasConcept C526805850 @default.
• W2890912772 hasConcept C71924100 @default.
• W2890912772 hasConcept C86803240 @default.

• next