Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890913550> ?p ?o ?g. }
- W2890913550 endingPage "2447" @default.
- W2890913550 startingPage "2443" @default.
- W2890913550 abstract "The tyrosine side chain is amphiphilic leading to significant variations in the surface exposure of tyrosine residues in the folded structure of a native sequence protein. This variability can be exploited to give residue-selective functionalization of a protein substrate by using a highly reactive diazonium group tethered to an agarose-based resin. This novel catch-and-release approach to protein modification has been demonstrated for proteins with accessible tyrosine residues, which are compared with a control group of proteins in which there are no accessible tyrosine residues. MS analysis of the modified proteins showed that functionalization was highly selective, but reactivity was further attenuated by the electrostatic environment of any individual residue. Automated screening of PDB structures allows identification of potential candidates for selective modification by comparison with the accessibility of the tyrosine residue in a benchmark peptide (GYG)." @default.
- W2890913550 created "2018-09-27" @default.
- W2890913550 creator A5007171299 @default.
- W2890913550 creator A5013138887 @default.
- W2890913550 creator A5021096925 @default.
- W2890913550 creator A5037492980 @default.
- W2890913550 creator A5040158927 @default.
- W2890913550 creator A5064579475 @default.
- W2890913550 date "2018-11-05" @default.
- W2890913550 modified "2023-09-27" @default.
- W2890913550 title "A Catch‐and‐Release Approach to Selective Modification of Accessible Tyrosine Residues" @default.
- W2890913550 cites W1416261912 @default.
- W2890913550 cites W1484115349 @default.
- W2890913550 cites W1897236478 @default.
- W2890913550 cites W1959535923 @default.
- W2890913550 cites W1980491680 @default.
- W2890913550 cites W1984111577 @default.
- W2890913550 cites W2011407829 @default.
- W2890913550 cites W2014756142 @default.
- W2890913550 cites W2025747013 @default.
- W2890913550 cites W2027790609 @default.
- W2890913550 cites W2028550811 @default.
- W2890913550 cites W2045227999 @default.
- W2890913550 cites W2048885992 @default.
- W2890913550 cites W2055204581 @default.
- W2890913550 cites W2068265376 @default.
- W2890913550 cites W2071300717 @default.
- W2890913550 cites W2083843114 @default.
- W2890913550 cites W2108403040 @default.
- W2890913550 cites W2125232427 @default.
- W2890913550 cites W2151643182 @default.
- W2890913550 cites W2160900576 @default.
- W2890913550 cites W2161033541 @default.
- W2890913550 cites W2165168809 @default.
- W2890913550 cites W2254963963 @default.
- W2890913550 cites W2295408967 @default.
- W2890913550 cites W2315302880 @default.
- W2890913550 cites W2330889009 @default.
- W2890913550 cites W2409075805 @default.
- W2890913550 cites W2470831393 @default.
- W2890913550 cites W2486741991 @default.
- W2890913550 cites W2519279890 @default.
- W2890913550 cites W2523580724 @default.
- W2890913550 cites W2527322609 @default.
- W2890913550 cites W2534534291 @default.
- W2890913550 cites W2563086790 @default.
- W2890913550 cites W2592547407 @default.
- W2890913550 cites W2742650930 @default.
- W2890913550 cites W2792665070 @default.
- W2890913550 cites W4210813427 @default.
- W2890913550 cites W4231031309 @default.
- W2890913550 cites W4249313134 @default.
- W2890913550 cites W4252608160 @default.
- W2890913550 cites W4383480277 @default.
- W2890913550 doi "https://doi.org/10.1002/cbic.201800532" @default.
- W2890913550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30212615" @default.
- W2890913550 hasPublicationYear "2018" @default.
- W2890913550 type Work @default.
- W2890913550 sameAs 2890913550 @default.
- W2890913550 citedByCount "11" @default.
- W2890913550 countsByYear W28909135502020 @default.
- W2890913550 countsByYear W28909135502021 @default.
- W2890913550 countsByYear W28909135502022 @default.
- W2890913550 countsByYear W28909135502023 @default.
- W2890913550 crossrefType "journal-article" @default.
- W2890913550 hasAuthorship W2890913550A5007171299 @default.
- W2890913550 hasAuthorship W2890913550A5013138887 @default.
- W2890913550 hasAuthorship W2890913550A5021096925 @default.
- W2890913550 hasAuthorship W2890913550A5037492980 @default.
- W2890913550 hasAuthorship W2890913550A5040158927 @default.
- W2890913550 hasAuthorship W2890913550A5064579475 @default.
- W2890913550 hasBestOaLocation W28909135502 @default.
- W2890913550 hasConcept C100631289 @default.
- W2890913550 hasConcept C115537861 @default.
- W2890913550 hasConcept C147789679 @default.
- W2890913550 hasConcept C181199279 @default.
- W2890913550 hasConcept C184133267 @default.
- W2890913550 hasConcept C185592680 @default.
- W2890913550 hasConcept C21951064 @default.
- W2890913550 hasConcept C2776165026 @default.
- W2890913550 hasConcept C2779281246 @default.
- W2890913550 hasConcept C2781338088 @default.
- W2890913550 hasConcept C55493867 @default.
- W2890913550 hasConcept C71240020 @default.
- W2890913550 hasConceptScore W2890913550C100631289 @default.
- W2890913550 hasConceptScore W2890913550C115537861 @default.
- W2890913550 hasConceptScore W2890913550C147789679 @default.
- W2890913550 hasConceptScore W2890913550C181199279 @default.
- W2890913550 hasConceptScore W2890913550C184133267 @default.
- W2890913550 hasConceptScore W2890913550C185592680 @default.
- W2890913550 hasConceptScore W2890913550C21951064 @default.
- W2890913550 hasConceptScore W2890913550C2776165026 @default.
- W2890913550 hasConceptScore W2890913550C2779281246 @default.
- W2890913550 hasConceptScore W2890913550C2781338088 @default.
- W2890913550 hasConceptScore W2890913550C55493867 @default.
- W2890913550 hasConceptScore W2890913550C71240020 @default.
- W2890913550 hasFunder F4320334626 @default.
- W2890913550 hasFunder F4320334627 @default.