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- W2890913929 abstract "The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, cooperates with B-Myb to activate genes required for the G2 and M phases of the cell cycle. We have identified the domain in B-Myb that is essential for the assembly of the Myb–MuvB (MMB) complex. We determined a crystal structure that reveals how this B-Myb domain binds MuvB through the adaptor protein LIN52 and the scaffold protein LIN9. The structure and biochemical analysis provide an understanding of how oncogenic B-Myb is recruited to regulate genes required for cell-cycle progression, and the MMB interface presents a potential therapeutic target to inhibit cancer cell proliferation." @default.
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- W2890913929 date "2018-09-17" @default.
- W2890913929 modified "2023-10-16" @default.
- W2890913929 title "Structural mechanism of Myb–MuvB assembly" @default.
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- W2890913929 doi "https://doi.org/10.1073/pnas.1808136115" @default.
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